⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31097915 | 0.88 | — | — | |
| SCHEMBL11189349 | 0.80 | — | — | |
| SCHEMBL28479248 | 0.76 | — | — | |
| SCHEMBL1572254 | 0.74 | — | — | |
| SCHEMBL15422795 | 0.73 | NOS1 (0.31) | — | |
| Hydrazine SCHEMBL1572402 | 0.70 | KDM1A (0.30) | — | |
| SCHEMBL11702792 | 0.69 | — | — | |
| SCHEMBL821855 | 0.69 | — | — | |
| SCHEMBL29493533 | 0.68 | — | — | |
| SCHEMBL9430980 | 0.67 | MAPT (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1175383-B1 | GLUCOCORTICOID RECEPTOR MODULATORS | PFIZER PROD INC (US) | 2018-03-14 | — | — | EP | disclosed |
| EP-1521733-B1 | MODULATORS OF THE GLUCOCORTICOID RECEPTOR | PFIZER PROD INC (US) | 2014-08-20 | — | — | EP | disclosed |
| US-7713989-B2 | Glucocorticoid receptor modulators | DOW ROBERT L | 2010-05-11 | — | — | US | disclosed |
| US-7553877-B2 | Use of 2-hydroxy-1,2,3,4,4a,9,10,10a-octahydrophenanthrene compounds glucocorticoid receptor agonists to treat certain inflammatory conditions such as arthritis, asthma | PFIZER, INC. (US) | 2009-06-30 | — | — | US | disclosed |
| US-20070129410-A1 | Octahydrophenanthrene hydrazinde derivatives useful as glucocorticoid receptor modulators | PFIZER INC. | 2007-06-07 | — | — | US | disclosed |
| US-20070117805-A1 | Glucocorticoid receptor modulators | PFIZER INC. | 2007-05-24 | — | — | US | disclosed |
| US-7166593-B2 | Glucocorticoid receptor modulators | PFIZER, INC. (US) | 2007-01-23 | — | — | US | disclosed |
| US-7138406-B2 | Antiinflammatory agents; antiallergens; vision defects; anticancer agents; gastrointestinal disorders | PFIZER, INC. (US) | 2006-11-21 | — | — | US | disclosed |
| US-20060247264-A1 | Use of 2-hydroxy-1,2,3,4,4a,9,10,10a-octahydrophenanthrene compounds glucocorticoid receptor agonists to treat certain inflammatory conditions such as arthritis, asthma | PFIZER INC | 2006-11-02 | — | — | US | disclosed |
| EP-1685110-A1 | OCTAHYDROPHENANTHRENE HYDRAZIDE DERIVATIVES USEFUL AS GLUCOCORTICOID RECEPTOR MODULATORS | Pfizer Products Inc. (US) | 2006-08-02 | — | — | EP | disclosed |
| US-20020107235-A1 | Glucocorticoid receptor modulators | LIU KEVIN K (US) | 2002-08-08 | — | — | US | disclosed |
| EP-1201649-A1 | Glucocorticoid receptor modulators | Pfizer Products Inc. (US) | 2002-05-02 | — | — | EP | disclosed |
| EP-1201660-A1 | Glucocorticoid receptor modulators | Pfizer Products Inc. (US) | 2002-05-02 | — | — | EP | disclosed |
| US-6380223-B1 | FOR THERAPY OF DISEASES, SUCH AS OBESITY, DIABETES, INFLAMMATION | PFIZER INC. | 2002-04-30 | — | — | US | disclosed |
| EP-1175383-A1 | GLUCOCORTICOID RECEPTOR MODULATORS | Pfizer Products Inc. (US) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000066522-A1 | GLUCOCORTICOID RECEPTOR MODULATORS | PFIZER PRODUCTS INC. (US) | 2000-11-09 | — | — | WO | disclosed |
| US-5276053-A | Dibenzothiopyranylamines | WARNER-LAMBERT COMPANY (US) | 1994-01-04 | — | — | US | disclosed |
| US-5180736-A | Treatment and prevention of brain disorders | WARNER-LAMBERT COMPANY (US) | 1993-01-19 | — | — | US | disclosed |
| US-5071853-A | Amine-substituted hexahydroindeno(2,1-b)pyrroles, -indeno(2,1-c)pyridines or -indeno(2,1-d)azepines; cerebral ischemia or infarction | WARNER-LAMBERT COMPANY | 1991-12-10 | — | — | US | disclosed |
| EP-0388977-A2 | Polycyclic amines useful as cerebrovascular agents | WARNER-LAMBERT COMPANY (US) | 1990-09-26 | — | — | EP | disclosed |