Hydrazine

Hydrazine

SCHEMBL1572402

C1=CC2=CC=C3CCCCC3C2CC1.NN

nearest known ligand 0.30

Full drug profile on Sugi Atlas →

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11702792 0.97
SCHEMBL821855 0.97
SCHEMBL486034 0.75 ESR1 (0.36) KDM1A
SCHEMBL31097915 0.73
SCHEMBL6249683 0.72 CYP19A1 (0.32)
SCHEMBL6249751 0.72 CYP19A1 (0.32)
SCHEMBL3304813 0.70
SCHEMBL9430980 0.70 MAPT (0.40)
SCHEMBL5378612 0.67
SCHEMBL11817035 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210128584-A1 USE OF GLUCOCORTICOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS CORCEPT THERAPEUTICS INCORPORATED 2021-05-06 US claimed
US-20140005158-A1 USE OF MIFEPRISTONE FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS CORCEPT THERAPEUTICS, INC. (US) 2014-01-02 US claimed
US-20110166115-A1 USE OF MIFEPRISTONE FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS CORCEPT THERAPEUTICS, INC. (US) 2011-07-07 US claimed
EP-2306830-A1 USE OF MIFEPRISTONE FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS Corcept Therapeutics, Inc. (US) 2011-04-13 EP claimed
US-20100179115-A1 USE OF A GLUCOCORTICOID RECEPTOR II ANTAGONIST TO TREAT DEPRESSION IN PATIENTS TAKING IL-2 CORCEPT THERAPEUTICS, INC. (US) 2010-07-15 US claimed
WO-2010002901-A1 USE OF MIFEPRISTONE FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS CORCEPT THERAPEUTICS, INC. (US) 2010-01-07 WO claimed
EP-2012796-A2 THE USE OF A GLUCOCORTICOID RECEPTOR II ANTAGONIST TO TREAT DEPRESSION IN PATIENTS TAKING IL-2 Corcept Therapeutics, Inc. (US) 2009-01-14 EP claimed
WO-2007131041-A2 THE USE OF A GLUCOCORTICOID RECEPTOR II ANTAGONIST TO TREAT DEPRESSION IN PATIENTS TAKING IL-2 CORCEPT THERAPEUTICS, INC. (US) 2007-11-15 WO claimed
US-20210128584-A1 USE OF GLUCOCORTICOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS CORCEPT THERAPEUTICS INCORPORATED 2021-05-06 US disclosed
EP-2576582-B1 TREATMENT OF MUSCULAR DYSTROPHY CORCEPT THERAPEUTICS INC (US) 2019-09-18 EP disclosed
US-20140005158-A1 USE OF MIFEPRISTONE FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS CORCEPT THERAPEUTICS, INC. (US) 2014-01-02 US disclosed
EP-2576582-A1 TREATMENT OF MUSCULAR DYSTROPHY Corcept Therapeutics, Inc. (US) 2013-04-10 EP disclosed
WO-2011150209-A1 TREATMENT OF MUSCULAR DYSTROPHY CORCEPT THERAPEUTICS, INC. (US) 2011-12-01 WO disclosed
US-20110294771-A1 TREATMENT OF MUSCULAR DYSTROPHY CORCEPT THERAPEUTICS, INC. (US) 2011-12-01 US disclosed
US-20110166115-A1 USE OF MIFEPRISTONE FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS CORCEPT THERAPEUTICS, INC. (US) 2011-07-07 US disclosed
US-20100179115-A1 USE OF A GLUCOCORTICOID RECEPTOR II ANTAGONIST TO TREAT DEPRESSION IN PATIENTS TAKING IL-2 CORCEPT THERAPEUTICS, INC. (US) 2010-07-15 US disclosed
EP-2012796-A2 THE USE OF A GLUCOCORTICOID RECEPTOR II ANTAGONIST TO TREAT DEPRESSION IN PATIENTS TAKING IL-2 Corcept Therapeutics, Inc. (US) 2009-01-14 EP disclosed
WO-2007131041-A2 THE USE OF A GLUCOCORTICOID RECEPTOR II ANTAGONIST TO TREAT DEPRESSION IN PATIENTS TAKING IL-2 CORCEPT THERAPEUTICS, INC. (US) 2007-11-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110166115-A1 USE OF MIFEPRISTONE FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS CRHR1, NR3C1, CRH KDM1A 3614/4885
US-20100179115-A1 USE OF A GLUCOCORTICOID RECEPTOR II ANTAGONIST TO TREAT DEPRESSION IN PATIENTS TAKING IL-2 CRHR2, IL2, GRIA2 KDM1A 4385/4885
US-20140005158-A1 USE OF MIFEPRISTONE FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS CRHR1, NR3C1, CRH KDM1A 3614/4885
US-20210128584-A1 USE OF GLUCOCORTICOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS NR3C1, CRHR1, NR3C2 KDM1A 4262/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.