Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.67 |
| ▸ | SRC | P12931 | 1/20 | 0.67 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14487045 | 0.82 | EGFR (0.67) | EGFRSRCNR4A2GAAPOLB | |
| SCHEMBL30608287 | 0.82 | EGFR (0.67) | EGFRSRCNR4A2GAAPOLB | |
| SCHEMBL13808717 | 0.81 | NR4A2 (0.64) | NR4A2GAAPOLBKMT2ARAB9A | |
| SCHEMBL8998976 | 0.81 | EGFR (0.79) | EGFRSRCGAAKMT2ARAB9A | |
| SCHEMBL8999391 | 0.80 | EGFR (1.00) | EGFRSRCGAAKMT2ARAB9A | |
| SCHEMBL570154 | 0.80 | NR4A2 (0.67) | NR4A2GAAKMT2ARAB9AALDH1A1 | |
| SCHEMBL28399070 | 0.80 | NR4A2 (0.55) | NR4A2GAAPOLBKMT2ARAB9A | |
| SCHEMBL24433085 | 0.78 | NR4A2 (0.65) | NR4A2GAAPOLBKMT2ARAB9A | |
| SCHEMBL27854856 | 0.78 | NR4A2 (0.69) | NR4A2GAAKMT2ARAB9AALDH1A1 | |
| SCHEMBL24538066 | 0.77 | NPC1 (0.64) | NR4A2GAAPOLBKMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100099732-A1 | MEDICAMENTS USEFUL AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-04-22 | — | — | US | claimed |
| EP-2139855-A1 | MEDICAMENTS USEFUL AS POTASSIUM CHANNEL MODULATORS | NeuroSearch A/S (DK) | 2010-01-06 | — | — | EP | claimed |
| WO-2008113747-A1 | MEDICAMENTS USEFUL AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2008-09-25 | — | — | WO | claimed |
| US-20100099732-A1 | MEDICAMENTS USEFUL AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-04-22 | — | — | US | disclosed |
| US-20100099732-A1 | MEDICAMENTS USEFUL AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-04-22 | — | — | US | disclosed |
| EP-2139855-A1 | MEDICAMENTS USEFUL AS POTASSIUM CHANNEL MODULATORS | NeuroSearch A/S (DK) | 2010-01-06 | — | — | EP | disclosed |
| EP-2139855-A1 | MEDICAMENTS USEFUL AS POTASSIUM CHANNEL MODULATORS | NeuroSearch A/S (DK) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008113747-A1 | MEDICAMENTS USEFUL AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2008-09-25 | — | — | WO | disclosed |
| WO-2008113747-A1 | MEDICAMENTS USEFUL AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2008-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099732-A1 | MEDICAMENTS USEFUL AS POTASSIUM CHANNEL MODULATORS | KCNN2, KCNN1, KCNN3 | EGFR 4594/4885SRC 1517/4885NR4A2 3034/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.