SCHEMBL8998976

SCHEMBL8998976

CSc1[nH]c2ccccc2c1C(=O)Nc1ccccc1

nearest known ligand 0.79

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
EGFR P00533 7/20 0.79
SRC P12931 5/20 0.79
ADORA3 P0DMS8 1/20 0.50
CCNA2 P20248 1/20 0.47
CDK2 P24941 1/20 0.47
FLT3 P36888 1/20 0.47
CCNA1 P78396 1/20 0.47
NPC1 O15118 4/20 0.46
RAB9A P51151 3/20 0.46
FGFR1 P11362 1/20 0.46
KMT2A Q03164 2/20 0.45
MEN1 O00255 1/20 0.45
CFTR P13569 1/20 0.45
LMNA P02545 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
GAA P10253 1/20 0.44
ALDH1A1 P00352 1/20 0.44
SLC22A12 Q96S37 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8999391 0.88 EGFR (1.00) EGFRSRCADORA3CCNA2CDK2
SCHEMBL8999074 0.84 EGFR (0.80) EGFRSRCNPC1RAB9AKMT2A
SCHEMBL3307083 0.81 EGFR (0.67) EGFRSRCADORA3CCNA2CDK2
SCHEMBL8999075 0.81 EGFR (0.80) EGFRSRCKMT2AMEN1GAA
SCHEMBL397184 0.75 KDM4E (0.53) EGFRSRCNPC1RAB9AKMT2A
SCHEMBL2069110 0.72 KMT2A (0.78) EGFRNPC1RAB9AKMT2AMEN1
SCHEMBL11442193 0.70 EGFR (0.57) EGFRSRCADORA3CCNA2CDK2
Carbazole SCHEMBL28283104 0.70 KMT2A (0.73) EGFRSRCADORA3NPC1RAB9A
SCHEMBL11280137 0.69 EGFR (0.56) EGFRSRCADORA3NPC1RAB9A
SCHEMBL24896433 0.69 ADORA3 (0.57) EGFRSRCADORA3CCNA2CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5556874-A ENZYME INHIBITORS AS ANTICARCINOGENIC AGENTS WARNER LAMBERT COMPANY (US) 1996-09-17 US disclosed
US-5464861-A Anticarcinogenic agents WARNER-LAMBERT (US) 1995-11-07 US disclosed
EP-0654024-A1 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES WARNER-LAMBERT COMPANY (US) 1995-05-24 EP disclosed
WO-1994003427-A1 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES WARNER-LAMBERT COMPANY (US) 1994-02-17 WO disclosed