Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GNAI3 | P08754 | 6/20 | 0.36 |
| ▸ | GNAO1 | P09471 | 6/20 | 0.36 |
| ▸ | GNAI1 | P63096 | 6/20 | 0.36 |
| ▸ | ARG1 | P05089 | 1/20 | 0.34 |
| ▸ | ARG2 | P78540 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1206066 | 0.86 | SIGMAR1 (0.50) | SIGMAR1ITGB3ITGA2BALDH1A1TSHR | |
| SCHEMBL28816385 | 0.82 | SIGMAR1 (0.59) | SIGMAR1ITGB3ITGA2BMEN1KMT2A | |
| SCHEMBL598086 | 0.78 | SIGMAR1 (0.52) | SIGMAR1ITGB3ITGA2BALDH1A1TSHR | |
| SCHEMBL3311740 | 0.76 | SMN1; SMN2 (0.53) | ALDH1A1TSHRKMT2AKDM4E | |
| SCHEMBL1207210 | 0.74 | SIGMAR1 (0.44) | SIGMAR1ALDH1A1TSHRKMT2AKDM4E | |
| SCHEMBL29364909 | 0.74 | SIGMAR1 (0.50) | SIGMAR1ITGB3ITGA2BMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8479792 | 0.74 | KMT2A (0.41) | ITGB3ITGA2BALDH1A1TSHRMEN1 | |
| SCHEMBL22500187 | 0.73 | SIGMAR1 (0.48) | SIGMAR1ALDH1A1NPSR1 | |
| SCHEMBL29004649 | 0.73 | SIGMAR1 (0.48) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL1461790 | 0.73 | SMN1; SMN2 (0.49) | ALDH1A1TSHRKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113411-A1 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2010-05-06 | — | — | US | disclosed |
| US-7595312-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2009-09-29 | — | — | US | disclosed |
| US-20060079504-A1 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO., KG (DE) | 2006-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113411-A1 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | CALCRL, CALCR, CALCA | SIGMAR1 402/4885ITGB3 3048/4885ITGA2B 3269/4885 |
| US-20060079504-A1 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | CALCRL, CALCR, CALCA | SIGMAR1 402/4885ITGB3 3048/4885ITGA2B 3269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.