Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3312479 | 0.85 | ALDH1A1 (0.60) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL3315348 | 0.84 | ALDH1A1 (0.42) | ALDH1A1LMNAKMT2AMEN1POLB | |
| SCHEMBL15507732 | 0.83 | ALDH1A1 (0.59) | ALDH1A1LMNASIRT6MAPTPOLB | |
| SCHEMBL2482642 | 0.78 | SIRT6 (0.55) | ALDH1A1LMNASIRT6MAPTKDM4E | |
| SCHEMBL1230074 | 0.77 | ALDH1A1 (0.77) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL2480471 | 0.76 | ALDH1A1 (0.54) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL31481091 | 0.76 | MAPT (0.56) | ALDH1A1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL2207917 | 0.76 | ALDH1A1 (0.56) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL12312156 | 0.75 | ALDH1A1 (0.71) | ALDH1A1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL29833145 | 0.75 | ALDH1A1 (0.71) | ALDH1A1LMNAMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |
| US-20100105655-A1 | NOVEL COMPOUNDS 515 | ASTRAZENECA AB | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105655-A1 | NOVEL COMPOUNDS 515 | TYMS, ABCG2, UMPS | ALDH1A1 649/4885LMNA 3341/4885SIRT6 1324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.