Afalanine

Afalanine

SCHEMBL331330

CC(=O)N[C@H](Cc1ccccc1)C(=O)O

nearest known ligand 0.66

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CTSS P25774 1/20 0.65
CTSK P43235 1/20 0.65
PAM P19021 1/20 0.65
GNPAT O15228 1/20 0.63
MME P08473 3/20 0.63
L3MBTL1 Q9Y468 1/20 0.62
NPSR1 Q6W5P4 1/20 0.61
CTRB1 P17538 4/20 0.60
LMNA P02545 1/20 0.60
NAALAD2 Q9Y3Q0 1/20 0.59
TACR1 P25103 1/20 0.58
ACE P12821 2/20 0.57
CPA1 P15085 2/20 0.57
ACE2 Q9BYF1 2/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Afalanine SCHEMBL8587729 1.00 CTSS (0.65) CTSSCTSKPAMGNPATMME
Afalanine SCHEMBL158613 1.00 CTSS (0.65) CTSSCTSKPAMGNPATMME
Afalanine SCHEMBL158612 1.00 CTSS (0.65) CTSSCTSKPAMGNPATMME
Afalanine SCHEMBL11167745 0.98 CTSS (0.63) CTSSCTSKPAMGNPATMME
Afalanine SCHEMBL28376591 0.98 CTSS (0.63) CTSSCTSKPAMGNPATMME
Afalanine SCHEMBL27807237 0.98 CTSS (0.63) CTSSCTSKPAMGNPATMME
Afalanine SCHEMBL8054139 0.98 CTSS (0.63) CTSSCTSKPAMGNPATMME
Afalanine SCHEMBL8054567 0.98 CTSS (0.63) CTSSCTSKPAMGNPATMME
Afalanine SCHEMBL5493802 0.98 CTSS (0.68) CTSSCTSKPAMGNPATMME
Afalanine SCHEMBL27738957 0.98 CTSS (0.63) CTSSCTSKPAMGNPATMME

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 464 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260132101-A1 METHOD FOR RESOLVING PHENYLALANINE DERIVATIVE, AND INTERMEDIATE NEUBORON BIO SCITECH CO LTD (CN) 2026-05-14 US claimed
EP-3375771-B1 METHOD FOR PRODUCING LACOSAMIDE AND INTERMEDIATE THEREOF UBE CORP (JP) 2025-11-26 EP claimed
CN-119330846-A Resolution method and intermediate of phenylalanine derivatives 中硼(厦门)生物医药有限公司 2025-01-21 CN claimed
EP-3406261-B1 SYNTHETIC ANTIGENIC PEPTIDES AND LIPOPEPTIDES DERIVED FROM MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS PASTEUR INSTITUT (FR) 2024-08-21 EP claimed
CN-117510398-A Preparation method of (3R, 4R)/(3S, 4S) -N-BOC-4-amino-3-hydroxy piperidine with high optical purity 上海诺丁太生物科技有限公司 2024-02-06 CN claimed
US-20240002438-A1 MELANOCORTIN LIGANDS AND METHODS OF USE THEREOF THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES 2024-01-04 US claimed
CN-116970008-A Nickel complex of N-acetyl-D-phenylalanine, preparation method and application thereof 河北师范大学 2023-10-31 CN claimed
CN-116660543-A Diagnostic and prognostic markers for nonalcoholic fatty liver disease and uses thereof 中国人民解放军陆军军医大学第一附属医院 2023-08-29 CN claimed
EP-4171621-A1 C825 EXPRESSING IMMUNE CELLS AND DIAGNOSTIC USES THEREOF Memorial Sloan Kettering Cancer Center (US) 2023-05-03 EP claimed
EP-4157293-A1 ANTI-GD2 SADA CONJUGATES AND USES THEREOF Memorial Sloan Kettering Cancer Center (US) 2023-04-05 EP claimed
US-5916774-A PRODUCES D-AMINO ACIDS FROM CORRESPONDING N-ACETYL-D-AMINO ACIDS; ACTIVITY PROMOTED BY COBALT AND CALCIUM IONS BUT INHIBITED BY COPPER, MERCURY AND ZINC IONS DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1999-06-29 US claimed
EP-0896057-A2 D-aminoacylase DAICEL CHEMICAL INDUSTRIES, Ltd. (JP) 1999-02-10 EP claimed
EP-0723586-A1 ENZYME AND ITS USE IN PREPARING (S)-PIPECOLIC ACID Chiroscience Limited (GB) 1996-07-31 EP claimed
WO-1995010604-A1 ENZYME AND ITS USE IN PREPARING (S)-PIPECOLIC ACID CHIROSCIENCE LIMITED (GB) 1995-04-20 WO claimed
EP-0174981-A4 METHOD OF TREATING DEPRESSION IN VERTEBRATES. ERK VERNON 1987-11-09 EP claimed
EP-0174981-A1 METHOD OF TREATING DEPRESSION IN VERTEBRATES. ERK VERNON 1986-03-26 EP claimed
WO-1985003874-A1 METHOD OF TREATING DEPRESSION IN VERTEBRATES ERK VERNON 1985-09-12 WO claimed
EP-0028251-B1 PROCESS FOR PRODUCING N-ACYL-D-PHENYLALANINE ESTER ETHYL CORPORATION (US) 1983-03-16 EP claimed
US-3983162-A Optical resolution of alkyl esters of DL-phenylalanine G. D. SEARLE & CO. (US) 1976-09-28 US claimed
US-3941831-A Resolution of alkyl esters of DL-phenylalanine G. D. SEARLE & CO. (US) 1976-03-02 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260132101-A1 METHOD FOR RESOLVING PHENYLALANINE DERIVATIVE, AND INTERMEDIATE ADH1A, ADH5, NAT1 CTSS 1646/4885CTSK 2959/4885PAM 2405/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.