Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.47 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2038362 | 0.89 | HTR1A (0.51) | HTR1ADRD2LRRK2CYP11B1CYP11B2 | |
| SCHEMBL17323482 | 0.83 | HTR1A (0.54) | HTR1ADRD2CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL1028598 | 0.83 | HTR1A (0.61) | HTR1ADRD2CYP11B1CYP11B2SGMS2 | |
| SCHEMBL3915787 | 0.82 | APP (0.51) | HTR1ADRD2F10LTA4HMAPK14 | |
| SCHEMBL31501865 | 0.82 | APP (0.51) | HTR1ADRD2F10LTA4HMAPK14 | |
| SCHEMBL17629916 | 0.80 | CYP11B1 (0.50) | HTR1ADRD2LRRK2CYP11B1CYP11B2 | |
| SCHEMBL3316338 | 0.78 | CYP11B1 (0.53) | HTR1ADRD2LRRK2CYP11B1CYP11B2 | |
| SCHEMBL29857565 | 0.77 | LTA4H (0.73) | HTR1ADRD2CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL26917169 | 0.77 | LTA4H (0.73) | HTR1ADRD2CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL29953323 | 0.77 | LRRK2 (0.50) | HTR1ADRD2LRRK2CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100105683-A1 | COMPOUNDS USEFUL FOR INHIBITING CHK1 | KEEGAN KATHLEEN S | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105683-A1 | COMPOUNDS USEFUL FOR INHIBITING CHK1 | CHEK1, PCNA, CHEK2 | HTR1A 4365/4885DRD2 4309/4885LRRK2 506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.