Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 10/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.44 |
| ▸ | LSS | P48449 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7704309 | 1.00 | DNM1 (0.50) | DNM1TSHRALDH1A1TP53CYP3A4 | |
| Bromide SCHEMBL8853213 | 1.00 | DNM1 (0.50) | DNM1TSHRALDH1A1TP53CYP3A4 | |
| Bromide SCHEMBL28594641 | 1.00 | DNM1 (0.50) | DNM1TSHRALDH1A1TP53CYP3A4 | |
| Bromide SCHEMBL28597017 | 1.00 | DNM1 (0.50) | DNM1TSHRALDH1A1TP53CYP3A4 | |
| Bromide SCHEMBL11164888 | 1.00 | DNM1 (0.50) | DNM1TSHRALDH1A1TP53CYP3A4 | |
| Bromide SCHEMBL7901612 | 1.00 | DNM1 (0.50) | DNM1TSHRALDH1A1TP53CYP3A4 | |
| Bromide SCHEMBL5550538 | 1.00 | DNM1 (0.50) | DNM1TSHRALDH1A1TP53CYP3A4 | |
| Bromide SCHEMBL11169923 | 1.00 | DNM1 (0.50) | DNM1TSHRALDH1A1TP53CYP3A4 | |
| Bromide SCHEMBL22159436 | 1.00 | DNM1 (0.50) | DNM1TSHRALDH1A1TP53CYP3A4 | |
| Decane SCHEMBL7901634 | 0.98 | DNM1 (0.48) | DNM1TSHRALDH1A1TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4348380-A | CYCLOPOLYMERIZED SALT OF ALKYL DIALLYLAMINE | L'OREAL (FR) | 1982-09-07 | — | — | US | claimed |
| EP-2660252-A2 | POLYSACCHARIDE-BASED GRAFT COPOLYMER AND COMPOSITION COMPRISING SAME FOR PERSONAL CARE | Kci Limited (KR) | 2013-11-06 | — | — | EP | disclosed |
| US-8562838-B2 | Method for treating mineral sludge above ground using polymers | SNF S.A.S. (FR) | 2013-10-22 | — | — | US | disclosed |
| US-20130272989-A1 | POLYSACCHARIDE-BASED GRAFT COPOLYMER AND COMPOSITION COMPRISING SAME FOR PERSONAL CARE | KCI LIMITED (KR) | 2013-10-17 | — | — | US | disclosed |
| US-7906567-B2 | Process for producing encapsulated product, and encapsulated product | SEIKO EPSON CORPORATION (JP) | 2011-03-15 | — | — | US | disclosed |
| US-20100105976-A1 | Method for treating mineral sludge above ground using polymers | SNF S.A.S. (FR) | 2010-04-29 | — | — | US | disclosed |
| US-20080039550-A1 | Process for producing encapsulated product, and encapsulated product | SEIKO EPSON CORPORATION | 2008-02-14 | — | — | US | disclosed |
| US-20070190021-A1 | Poly(diallylamine)-based bile acid sequestrants | HOLMES-FARLEY STEPHEN R | 2007-08-16 | — | — | US | disclosed |
| US-7125547-B2 | Poly(diallylamine)-based bile acid sequestrants | GENZYME CORPORATION (US) | 2006-10-24 | — | — | US | disclosed |
| US-20040151687-A1 | Poly(diallylamine)-based bile acid sequestrants | GENZYME CORPORATION | 2004-08-05 | — | — | US | disclosed |
| WO-1999022743-A1 | POLY(DIALLYLAMINE)-BASED PHOSPHATE BINDERS | GELTEX PHARMACEUTICALS, INC. (US) | 1999-05-14 | — | — | WO | disclosed |
| WO-1998029107-A2 | POLY(DIALLYLAMINE)-BASED BILE ACID SEQUESTRANTS | GELTEX PHARMACEUTICALS, INC. (US) | 1998-07-09 | — | — | WO | disclosed |
| US-5624570-A | CLARIFICATION OF WASH WATER WITH POLYMER AND CATIONIC, NONIONIC OR ANIONIC ACRYLAMIDE POLYMER WITH DIMETHYL DALLYL AMMONIUM CHLORIDE | CALGON CORPORATION (US) | 1997-04-29 | — | — | US | disclosed |
| EP-0526800-A1 | Polymers from N-containing monomers polymerised in the presence of monosaccharids, oligosaccharids or polysaccharids and derivatives | BASF Aktiengesellschaft (DE) | 1993-02-10 | — | — | EP | disclosed |
| US-5101047-A | Sulfobetaine-substituted α-sulfonylcarboxylic acids from diallylammonium salts and a process for the preparation thereof | BALLSCHUH DETLEF (DE) | 1992-03-31 | — | — | US | disclosed |
| US-5099043-A | 3-METHYLSULFONYLMETHYL-4-SULFOMETHYL-PYRROLIDINIUM-BETAINES AND PROCESS FOR THEIR PREPARATION | BALLSCHUH DETLEF (DE) | 1992-03-24 | — | — | US | disclosed |
| EP-0434175-A1 | Sulphobetain-substituted alpha-sulphonyl carboxylic acids from diallylammonium salts and process for their preparation | INSTITUT FÜR CHEMISCHE TECHNOLOGIE (DE) | 1991-06-26 | — | — | EP | disclosed |
| EP-0434174-A1 | 3-Methylsulfonylmethyl-4-sulfomethyl-pyrrolidinium betains and process for their preparation | INSTITUT FÜR CHEMISCHE TECHNOLOGIE (DE) | 1991-06-26 | — | — | EP | disclosed |
| US-4410709-A | Sulfobetaines | AKADEMIE DER WISSENSCHAFTEN DER DDR (DD) | 1983-10-18 | — | — | US | disclosed |
| US-4283384-A | Cosmetic compositions containing polymers produced in the presence of cerium ions | L'OREAL (FR) | 1981-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070190021-A1 | Poly(diallylamine)-based bile acid sequestrants | NR1H4, SLC10A2, SLC10A1 | DNM1 3581/4885TSHR 4075/4885ALDH1A1 2873/4885 |
| US-20130272989-A1 | POLYSACCHARIDE-BASED GRAFT COPOLYMER AND COMPOSITION COMPRISING SAME FOR PERSONAL CARE | PHOSPHO1, ALG1, PHYKPL | DNM1 4049/4885TSHR 4730/4885ALDH1A1 3090/4885 |
| US-20040151687-A1 | Poly(diallylamine)-based bile acid sequestrants | NR1H4, SLC10A2, SLC10A1 | DNM1 3469/4885TSHR 4388/4885ALDH1A1 2717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.