Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3313112 | 1.00 | NPC1 (0.40) | NPC1RAB9ASIGMAR1MTORLMNA | |
| SCHEMBL4385742 | 0.86 | OPRM1 (0.39) | NPC1RAB9ASIGMAR1LMNAACHE | |
| Hydrochloric Acid SCHEMBL3316281 | 0.85 | OPRM1 (0.39) | NPC1RAB9ASIGMAR1LMNAACHE | |
| Hydrochloric Acid SCHEMBL3314434 | 0.85 | OPRM1 (0.39) | NPC1RAB9ASIGMAR1LMNAACHE | |
| SCHEMBL566867 | 0.84 | JAK2 (0.42) | NPC1RAB9ASIGMAR1LMNAACHE | |
| SCHEMBL10099179 | 0.76 | SIGMAR1 (0.42) | NPC1RAB9ASIGMAR1LMNAACHE | |
| SCHEMBL13398079 | 0.76 | JAK1 (0.49) | MTORDRD4JAK2JAK1TYK2 | |
| SCHEMBL566703 | 0.75 | SIGMAR1 (0.45) | NPC1RAB9ASIGMAR1LMNAKDM4E | |
| SCHEMBL10099186 | 0.74 | LMNA (0.43) | NPC1RAB9ASIGMAR1LMNAACHE | |
| SCHEMBL10099144 | 0.72 | JAK1 (0.44) | NPC1RAB9ASIGMAR1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100105661-A1 | CONDENSED PYRIDINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2010-04-29 | — | — | US | disclosed |
| EP-2123651-A1 | CONDENSED PYRIDINE COMPOUND | Astellas Pharma Inc. (JP) | 2009-11-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105661-A1 | CONDENSED PYRIDINE COMPOUND | JAK3, IRAK3, JAK1 | NPC1 3583/4885RAB9A 3312/4885SIGMAR1 4631/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.