Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3328459 | 0.82 | HSD11B1 (1.00) | HSD11B1CYP3A4MEN1KMT2ATP53 | |
| SCHEMBL3323397 | 0.76 | HSD11B1 (1.00) | HSD11B1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL3322470 | 0.74 | HSD11B1 (0.67) | HSD11B1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL3327910 | 0.73 | HSD11B1 (1.00) | HSD11B1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL3323115 | 0.73 | HSD11B1 (0.65) | HSD11B1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL11967756 | 0.72 | HSD11B1 (0.57) | HSD11B1CYP3A4ALDH1A1NPC1 | |
| SCHEMBL3324100 | 0.72 | HSD11B1 (0.57) | HSD11B1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL3325992 | 0.72 | HSD11B1 (0.60) | HSD11B1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL3324146 | 0.71 | HSD11B1 (1.00) | HSD11B1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL3321009 | 0.71 | HSD11B1 (0.66) | HSD11B1CYP3A4ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100120789-A1 | Compound | STERIX LIMITED (GB) | 2010-05-13 | — | — | US | disclosed |
| US-20100120789-A1 | Compound | STERIX LIMITED (GB) | 2010-05-13 | — | — | US | disclosed |
| US-20100120789-A1 | Compound | STERIX LIMITED (GB) | 2010-05-13 | — | — | US | disclosed |
| US-20090042929-A1 | 11-Beta-Hydroxysteroid Dehydrogenase Inhibitors | STERIX LIMITED (GB) | 2009-02-12 | — | — | US | disclosed |
| US-20090042929-A1 | 11-Beta-Hydroxysteroid Dehydrogenase Inhibitors | STERIX LIMITED (GB) | 2009-02-12 | — | — | US | disclosed |
| EP-1861384-A1 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Sterix Limited (GB) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006100502-A1 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE INHIBITORS | STERIX LIMITED (GB) | 2006-09-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042929-A1 | 11-Beta-Hydroxysteroid Dehydrogenase Inhibitors | HSD3B1, HSD3B2, HSD11B1 | HSD11B1 3/4885CYP3A4 72/4885ALDH1A1 437/4885 |
| US-20100120789-A1 | Compound | NR0B2, NR0B1, NR4A1 | HSD11B1 73/4885CYP3A4 100/4885ALDH1A1 3143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.