Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 4/20 | 0.43 |
| ▸ | RAC1 | P63000 | 9/20 | 1.00 |
| ▸ | CDC42 | P60953 | 8/20 | 1.00 |
| ▸ | BAD | Q92934 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | RGS17 | Q9UGC6 | 2/20 | 0.45 |
| ▸ | GMNN | O75496 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13334159 | 0.98 | RAC1 (1.00) | RAC1CDC42BADALDH1A1MAPT | |
| SCHEMBL9681626 | 0.83 | RAC1 (0.79) | RAC1CDC42BADALDH1A1MAPT | |
| SCHEMBL15413681 | 0.82 | RAC1 (0.71) | RAC1CDC42BADALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL8709312 | 0.78 | RAC1 (0.70) | RAC1CDC42BADALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL3321466 | 0.78 | RAC1 (1.00) | RAC1CDC42BADALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL8709205 | 0.78 | RAC1 (0.70) | RAC1CDC42BADALDH1A1MAPT | |
| SCHEMBL13334193 | 0.76 | RAC1 (1.00) | RAC1CDC42BADALDH1A1MAPT | |
| SCHEMBL9679413 | 0.76 | RAC1 (0.69) | RAC1CDC42BADALDH1A1MAPT | |
| SCHEMBL9679427 | 0.76 | RAC1 (0.69) | RAC1CDC42BADALDH1A1MAPT | |
| SCHEMBL8712325 | 0.72 | RAC1 (0.61) | RAC1CDC42BADALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185521-A2 | COMPOUNDS AND METHODS FOR MODULATING RHO GTPASES | Exonhit Therapeutics SA (FR) | 2010-05-19 | — | — | EP | claimed |
| US-20100120810-A1 | COMPOUNDS AND METHODS FOR MODULATING RHO GTPASES | EXONHIT THERAPEUTICS SA (FR) | 2010-05-13 | — | — | US | claimed |
| WO-2009007457-A2 | COMPOUNDS AND METHODS FOR MODULATING RHO GTPASES | EXONHIT THERAPEUTICS SA (FR) | 2009-01-15 | — | — | WO | claimed |
| EP-2185521-A2 | COMPOUNDS AND METHODS FOR MODULATING RHO GTPASES | Exonhit Therapeutics SA (FR) | 2010-05-19 | — | — | EP | disclosed |
| US-20100120810-A1 | COMPOUNDS AND METHODS FOR MODULATING RHO GTPASES | EXONHIT THERAPEUTICS SA (FR) | 2010-05-13 | — | — | US | disclosed |
| WO-2009007457-A2 | COMPOUNDS AND METHODS FOR MODULATING RHO GTPASES | EXONHIT THERAPEUTICS SA (FR) | 2009-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120810-A1 | COMPOUNDS AND METHODS FOR MODULATING RHO GTPASES | RAC1, RAC2, RAC3 | ACHE 4129/4885RAC1 1/4885CDC42 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.