Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.61 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.56 |
| ▸ | CACNA1D | Q01668 | 3/20 | 0.56 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.56 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3330194 | 0.92 | ADORA3 (0.76) | TSHRKDM4EALDH1A1HSD17B10HTT | |
| SCHEMBL28735906 | 0.87 | TSHR (0.54) | TSHRKDM4EALDH1A1HSD17B10HTT | |
| SCHEMBL7436006 | 0.87 | TSHR (0.72) | TSHRKDM4EALDH1A1HSD17B10HTT | |
| SCHEMBL16137718 | 0.85 | TSHR (0.70) | TSHRKDM4EALDH1A1HSD17B10HTT | |
| SCHEMBL7881093 | 0.85 | ALDH1A1 (0.72) | TSHRKDM4EALDH1A1HSD17B10HTT | |
| SCHEMBL3017205 | 0.84 | KDM4E (0.76) | TSHRKDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL7879285 | 0.84 | CACNA1F (0.76) | TSHRKDM4EALDH1A1HSD17B10HTT | |
| SCHEMBL10895180 | 0.84 | CACNA1F (0.76) | TSHRKDM4EALDH1A1HSD17B10HTT | |
| SCHEMBL11817128 | 0.84 | KDM4E (0.76) | TSHRKDM4EALDH1A1HSD17B10HTT | |
| SCHEMBL3030162 | 0.84 | ALDH1A1 (0.59) | TSHRKDM4EALDH1A1HSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114516774-A | Preparation method of chiral bromo-1, 4-dihydropyridine compound | 中国科学院成都生物研究所 | 2022-05-20 | — | — | CN | disclosed |
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | ARCHER PHARMACEUTICALS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | ARCHER PHARMACEUTICALS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | ARCHER PHARMACEUTICALS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
| US-5559004-A | Methods for screening compounds to determine calcium leak channel inhibition activity | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1996-09-24 | — | — | US | disclosed |
| US-5559004-A | Methods for screening compounds to determine calcium leak channel inhibition activity | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1996-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | APP, MAPT, PSEN1 | TSHR 4847/4885KDM4E 4115/4885ALDH1A1 2615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.