Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | HTT | P42858 | 2/20 | 0.70 |
| ▸ | RAB9A | P51151 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 3/20 | 0.60 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.59 |
| ▸ | CACNA1D | Q01668 | 3/20 | 0.59 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.59 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7265410 | 0.94 | TSHR (0.65) | TSHRKDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL11009730 | 0.93 | TSHR (0.64) | TSHRKDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL7881093 | 0.88 | ALDH1A1 (0.72) | TSHRKDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL16137718 | 0.88 | TSHR (0.70) | TSHRKDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL10895180 | 0.87 | CACNA1F (0.76) | TSHRKDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL11817128 | 0.87 | KDM4E (0.76) | TSHRKDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL7879285 | 0.87 | CACNA1F (0.76) | TSHRKDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL3320696 | 0.87 | TSHR (0.68) | TSHRKDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL14638107 | 0.87 | TSHR (0.57) | TSHRKDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL3905675 | 0.86 | ADORA3 (0.83) | TSHRKDM4EALDH1A1HSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114516774-A | Preparation method of chiral bromo-1, 4-dihydropyridine compound | 中国科学院成都生物研究所 | 2022-05-20 | — | — | CN | disclosed |
| CN-110483563-B | Preparation method and application of novel ionic beta-naphthoic aldehyde Schiff base zirconium complex | 山西医科大学 | 2021-12-28 | — | — | CN | disclosed |
| US-5559004-A | Methods for screening compounds to determine calcium leak channel inhibition activity | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1996-09-24 | — | — | US | disclosed |
| US-5559004-A | Methods for screening compounds to determine calcium leak channel inhibition activity | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1996-09-24 | — | — | US | disclosed |
| US-5198226-A | Sustained release | SYNTEX (U.S.A.) INC. (US) | 1993-03-30 | — | — | US | disclosed |
| US-4940556-A | SUSTAINED RELEASE OF CALCIUM CHANNEL BLOCKERS | SYNTEX (U.S.A.) INC. (US) | 1990-07-10 | — | — | US | disclosed |
| EP-0301133-A2 | Long acting formulation | SYNTEX (U.S.A.) INC. (US) | 1989-02-01 | — | — | EP | disclosed |
| EP-0285267-A2 | Pyridine derivatives for treatment and prevention of liver damage, and their preparation | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1988-10-05 | — | — | EP | disclosed |