Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL20703698 | 0.96 | MEN1 (0.33) | MEN1HSP90AA1KMT2AATMRAPGEF4 | |
| Hydrochloric Acid SCHEMBL28406677 | 0.96 | MEN1 (0.33) | MEN1HSP90AA1KMT2AATMRAPGEF4 | |
| Hydrochloric Acid SCHEMBL1258347 | 0.95 | KMT2A (0.32) | MEN1HSP90AA1KMT2ARAPGEF4 | |
| Hydrochloric Acid SCHEMBL3625830 | 0.95 | KMT2A (0.32) | MEN1HSP90AA1KMT2ARAPGEF4 | |
| SCHEMBL699809 | 0.93 | MEN1 (0.35) | MEN1HSP90AA1KMT2AATMRAPGEF4 | |
| SCHEMBL699810 | 0.93 | MEN1 (0.35) | MEN1HSP90AA1KMT2AATMRAPGEF4 | |
| SCHEMBL4515332 | 0.93 | MEN1 (0.35) | MEN1HSP90AA1KMT2AATMRAPGEF4 | |
| SCHEMBL4515328 | 0.93 | MEN1 (0.35) | MEN1HSP90AA1KMT2AATMRAPGEF4 | |
| SCHEMBL31013359 | 0.93 | KMT2A (0.33) | MEN1HSP90AA1KMT2AATMRAPGEF4 | |
| Hydrochloric Acid SCHEMBL3625061 | 0.92 | KMT2A (0.32) | MEN1HSP90AA1KMT2ARAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943281-B1 | HYBRID CATALYST SYSTEMS SUPPORTED ON MAGNESIUM HALIDE | BASELL POLYOLEFINE GMBH (DE) | 2017-09-20 | — | — | EP | disclosed |
| US-7723448-B2 | Hybrid catalyst systems supported on magnesium halide | BASELL POLYOLEFINE GMBH (DE) | 2010-05-25 | — | — | US | disclosed |
| US-20090118445-A1 | Hybrid Catalyst Systems Supported On Magnesium Halide | BASELL POLYOLOLINE GMBH (DE) | 2009-05-07 | — | — | US | disclosed |