Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.69 |
| ▸ | RAB9A | P51151 | 6/20 | 0.69 |
| ▸ | MAPT | P10636 | 10/20 | 0.68 |
| ▸ | NPC1 | O15118 | 5/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.62 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.62 |
| ▸ | RELA | Q04206 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 6/20 | 0.58 |
| ▸ | GRM6 | O15303 | 3/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7023449 | 0.83 | MAPT (0.72) | ALDH1A1RAB9AMAPTNPC1MEN1 | |
| SCHEMBL27663685 | 0.82 | ALDH1A1 (0.71) | ALDH1A1RAB9AMAPTNPC1MEN1 | |
| SCHEMBL1143421 | 0.82 | MAPT (1.00) | ALDH1A1RAB9AMAPTNPC1MEN1 | |
| SCHEMBL12082955 | 0.78 | KDM4E (1.00) | ALDH1A1RAB9AMAPTNPC1MEN1 | |
| SCHEMBL11307879 | 0.78 | ALDH1A1 (0.78) | ALDH1A1RAB9AMAPTNPC1MEN1 | |
| SCHEMBL6030751 | 0.77 | ALDH1A1 (0.57) | ALDH1A1RAB9AMAPTNPC1MEN1 | |
| SCHEMBL27875666 | 0.77 | CISD2 (0.63) | ALDH1A1RAB9AMAPTNPC1MEN1 | |
| SCHEMBL9400304 | 0.76 | RAB9A (1.00) | ALDH1A1RAB9AMAPTNPC1MEN1 | |
| SCHEMBL9732938 | 0.76 | MAPT (0.78) | ALDH1A1RAB9AMAPTNPC1MEN1 | |
| SCHEMBL1638729 | 0.76 | ALDH1A1 (1.00) | ALDH1A1MAPTMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675861-B1 | PYRIMIDOTHIOPHENE COMPOUNDS | VERNALIS R&D LTD (GB) | 2015-12-23 | — | — | EP | disclosed |
| EP-1675861-B1 | PYRIMIDOTHIOPHENE COMPOUNDS | VERNALIS R&D LTD (GB) | 2015-12-23 | — | — | EP | disclosed |
| US-8642594-B2 | Substituted thieno[2,3-d]pyrimidines as HSP90 inhibitors | VERNALIS (R&D) LIMITED (GB) | 2014-02-04 | — | — | US | disclosed |
| US-8642594-B2 | Substituted thieno[2,3-d]pyrimidines as HSP90 inhibitors | VERNALIS (R&D) LIMITED (GB) | 2014-02-04 | — | — | US | disclosed |
| US-8642594-B2 | Substituted thieno[2,3-d]pyrimidines as HSP90 inhibitors | VERNALIS (R&D) LIMITED (GB) | 2014-02-04 | — | — | US | disclosed |
| US-7820658-B2 | Substituted thieno[2,3-d]pyrimidines as HSP90 inhibitors | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2010-10-26 | — | — | US | disclosed |
| US-7820658-B2 | Substituted thieno[2,3-d]pyrimidines as HSP90 inhibitors | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2010-10-26 | — | — | US | disclosed |
| US-7820658-B2 | Substituted thieno[2,3-d]pyrimidines as HSP90 inhibitors | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2010-10-26 | — | — | US | disclosed |
| US-20100120767-A1 | Pyrimidothiophene Compounds | Barril-Alonso, Xavier (GB) | 2010-05-13 | — | — | US | disclosed |
| US-20100120767-A1 | Pyrimidothiophene Compounds | Barril-Alonso, Xavier (GB) | 2010-05-13 | — | — | US | disclosed |
| US-20100120767-A1 | Pyrimidothiophene Compounds | Barril-Alonso, Xavier (GB) | 2010-05-13 | — | — | US | disclosed |
| CN-100455586-C | Pyrimidothiophene compounds | VERNALIS CAMBRIDGE LTD (GB) | 2009-01-28 | — | — | CN | disclosed |
| US-20070043044-A1 | Pyrimidothiophene compounds | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2007-02-22 | — | — | US | disclosed |
| US-20070043044-A1 | Pyrimidothiophene compounds | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2007-02-22 | — | — | US | disclosed |
| US-20070043044-A1 | Pyrimidothiophene compounds | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2007-02-22 | — | — | US | disclosed |
| CN-1842532-A | Pyrimidothiophene compounds | VERNALIS CAMBRIDGE LTD (GB) | 2006-10-04 | — | — | CN | disclosed |
| EP-1675861-A1 | PYRIMIDOTHIOPHENE COMPOUNDS | Vernalis (Cambridge) Limited (GB) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005021552-A1 | PYRIMIDOTHIOPHENE COMPOUNDS | VERNALIS (CAMBRIDGE) LTD (GB) | 2005-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120767-A1 | Pyrimidothiophene Compounds | ALK, HSP90AA1, HSP90AB1 | ALDH1A1 83/4885RAB9A 2450/4885MAPT 3898/4885 |
| US-20070043044-A1 | Pyrimidothiophene compounds | ALK, HSP90AA1, HSP90AB1 | ALDH1A1 91/4885RAB9A 2370/4885MAPT 3666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.