Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 8/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.44 |
| ▸ | GSK3B | P49841 | 6/20 | 0.44 |
| ▸ | PRKACA | P17612 | 5/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.44 |
| ▸ | CDK1 | P06493 | 4/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.44 |
| ▸ | PRKACG | P22612 | 4/20 | 0.44 |
| ▸ | PRKACB | P22694 | 4/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.44 |
| ▸ | CLK1 | P49759 | 4/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.44 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.44 |
| ▸ | CSNK1G2 | P78368 | 3/20 | 0.44 |
| ▸ | CSNK1G1 | Q9HCP0 | 3/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25183185 | 0.82 | KDM4E (0.35) | KDM4EALDH1A1ADORA2A | |
| SCHEMBL30956778 | 0.82 | KDM4E (0.35) | KDM4EALDH1A1ADORA2A | |
| SCHEMBL13992624 | 0.79 | KDM4E (0.41) | KDM4EALDH1A1CDK2DYRK1A | |
| SCHEMBL3331256 | 0.79 | MAPK13 (0.35) | KDM4EALDH1A1ADORA2A | |
| SCHEMBL5000417 | 0.76 | CDC7 (0.51) | KDM4EALDH1A1HSP90AA1GSK3BCCNB2 | |
| SCHEMBL3061377 | 0.75 | KDM4E (0.54) | KDM4EALDH1A1HSP90AA1CDK5CDK5R1 | |
| SCHEMBL4780028 | 0.73 | PRKACA (0.58) | KDM4EALDH1A1HSP90AA1CDK5CDK5R1 | |
| SCHEMBL3358493 | 0.72 | KDM4E (0.44) | KDM4EALDH1A1HSP90AA1PRKACAPDPK1 | |
| SCHEMBL18724191 | 0.72 | MAPT (0.53) | KDM4EALDH1A1CYP1A2 | |
| SCHEMBL623986 | 0.71 | ALDH1A1 (1.00) | KDM4EALDH1A1HSP90AA1PRKACAAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100130473-A1 | COMPOUNDS | HUMMERSONE MARC GEOFFREY | 2010-05-27 | — | — | US | disclosed |
| US-7504397-B2 | mTOR inhibitor compounds | KUDOS PHARMACEUTICALS LTD. (GB) | 2009-03-17 | — | — | US | disclosed |
| EP-1877388-A2 | HYDRAZINOMETHYL, HYDRAZONOMETHYL AND 5-MEMBERED HETEROCYLIC COMPOUNDS WHICH ACT AS MTOR INHIBITORS AND THEIR USE AS ANTI CANCER AGENTS | Kudos Pharmaceuticals Ltd (GB) | 2008-01-16 | — | — | EP | disclosed |
| US-20060199804-A1 | Compounds | KUDOS PHARMACEUTICALS LTD (GB) | 2006-09-07 | — | — | US | disclosed |
| WO-2006090167-A2 | HYDRAZINOMETHYL, HYDR ZONOMETHYL AND 5-MEMBERED HETEROCYLIC COMPOUNDS WHICH ACT AS MTOR INHIBITORS AND THEIR USE AS ANTI CANCER AGENTS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2006-08-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060199804-A1 | Compounds | CA4, CA6, CYP2B6 | KDM4E 2128/4885ALDH1A1 1821/4885HSP90AA1 3388/4885 |
| US-20100130473-A1 | COMPOUNDS | CA6, CYP2B6, CA4 | KDM4E 2214/4885ALDH1A1 1677/4885HSP90AA1 3138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.