Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.55 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3325935 | 0.78 | CHRNA7 (0.59) | CHRNA7CHRNA3CHRNA4HTR3A | |
| SCHEMBL373000 | 0.75 | CHRNA7 (0.59) | CHRNA7CHRNA3CHRNA4HTR3A | |
| SCHEMBL6565318 | 0.74 | CHRNA4 (0.48) | CHRNA4 | |
| SCHEMBL4208891 | 0.74 | CHRNA7 (0.61) | CHRNA7CHRNA3HTR3A | |
| Hydrochloric Acid SCHEMBL3327850 | 0.73 | CHRNA7 (0.56) | CHRNA7CHRNA3 | |
| SCHEMBL3328505 | 0.71 | CHRNA7 (0.58) | CHRNA7CHRNA3CHRNA4HTR3A | |
| SCHEMBL3331680 | 0.71 | CHRNA7 (1.00) | CHRNA7HTR3A | |
| SCHEMBL4702484 | 0.70 | CHRNA7 (0.48) | CHRNA7CHRNA3HTR3A | |
| SCHEMBL3515852 | 0.70 | CHRNA7 (0.48) | CHRNA7CHRNA3HTR3A | |
| SCHEMBL4032087 | 0.69 | L3MBTL3 (0.58) | CHRNA7CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100130483-A1 | NOVEL DIAZABICYCLIC ARYL DERIVATIVES | NEUROSEARCH A/S (DK) | 2010-05-27 | — | — | US | claimed |
| US-20060148789-A1 | Novel diazabicyclic aryl derivatives | NEUROSEARCH A/S (DK) | 2006-07-06 | — | — | US | claimed |
| US-20100130483-A1 | NOVEL DIAZABICYCLIC ARYL DERIVATIVES | NEUROSEARCH A/S (DK) | 2010-05-27 | — | — | US | disclosed |
| US-7678788-B2 | Diazabicyclic aryl derivatives | NEUROSEARCH A/S (DK) | 2010-03-16 | — | — | US | disclosed |
| EP-1599476-B1 | NOVEL DIAZABICYCLIC ARYL DERIVATIVES | NEUROSEARCH AS (DK) | 2009-10-14 | — | — | EP | disclosed |
| US-20060148789-A1 | Novel diazabicyclic aryl derivatives | NEUROSEARCH A/S (DK) | 2006-07-06 | — | — | US | disclosed |
| EP-1599476-A1 | NOVEL DIAZABICYCLIC ARYL DERIVATIVES | NEUROSEARCH A/S (DK) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004076453-A1 | NOVEL DIAZABICYCLIC ARYL DERIVATIVES | NEUROSEARCH A/S (DK) | 2004-09-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130483-A1 | NOVEL DIAZABICYCLIC ARYL DERIVATIVES | CHRNA6, CHRNA10, CHRNA2 | CHRNA7 6/4885CHRNA3 5/4885CHRNA4 7/4885 |
| US-20060148789-A1 | Novel diazabicyclic aryl derivatives | CHRNA6, CHRNA10, CHRNA2 | CHRNA7 6/4885CHRNA3 5/4885CHRNA4 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.