Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.59 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL373000 | 0.85 | CHRNA7 (0.59) | CHRNA7CHRNA3CHRNB2CHRNB4CHRNA4 | |
| SCHEMBL4208891 | 0.84 | CHRNA7 (0.61) | CHRNA7CHRNA3HTR3AL3MBTL3L3MBTL1 | |
| SCHEMBL3323822 | 0.78 | CHRNA7 (0.55) | CHRNA7CHRNA3CHRNA4HTR3A | |
| SCHEMBL3327298 | 0.78 | ALDH1A1 (0.54) | CHRNA7CHRNA4ALDH1A1KMT2AMEN1 | |
| SCHEMBL373086 | 0.78 | CHRNA7 (0.58) | CHRNA7ALDH1A1POLBNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL3325050 | 0.77 | ALDH1A1 (0.53) | CHRNA7CHRNA4ALDH1A1KMT2AMEN1 | |
| SCHEMBL4702386 | 0.76 | CHRNA7 (0.52) | CHRNA7NPC1HTR3A | |
| SCHEMBL3325793 | 0.76 | SCN5A (0.58) | CHRNA7ALDH1A1NPC1PKMRAB9A | |
| SCHEMBL4700316 | 0.76 | CHRNA7 (0.70) | CHRNA7CHRNA3NPC1RAB9AHTR3A | |
| SCHEMBL3326252 | 0.76 | CHRNA7 (0.52) | CHRNA7NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100130483-A1 | NOVEL DIAZABICYCLIC ARYL DERIVATIVES | NEUROSEARCH A/S (DK) | 2010-05-27 | — | — | US | claimed |
| EP-1539765-B1 | BIARYL DIAZABICYCLOALKANE AMIDES AS NICOTINIC ACETYLCHOLINE AGONISTS | ASTRAZENECA AB (SE) | 2008-12-10 | — | — | EP | claimed |
| US-20060148789-A1 | Novel diazabicyclic aryl derivatives | NEUROSEARCH A/S (DK) | 2006-07-06 | — | — | US | claimed |
| US-20060052368-A1 | Aryl-substituted diazabicycloalkanes as nicotinic acetylcholine agonists | ASTRAZENECA AB (SE) | 2006-03-09 | — | — | US | claimed |
| EP-1599476-A1 | NOVEL DIAZABICYCLIC ARYL DERIVATIVES | NEUROSEARCH A/S (DK) | 2005-11-30 | — | — | EP | claimed |
| US-20050239774-A1 | Biaryl diazabicycloalkane amides as nicotinic acetylcholine agonists | ASTRAZENECA AB (SE) | 2005-10-27 | — | — | US | claimed |
| EP-1539764-A1 | ARYL-SUBSTITUTED DIAZABICYCLOALKANES AS NICOTINIC ACETYLCHOLINE AGONISTS. | AstraZeneca AB (SE) | 2005-06-15 | — | — | EP | claimed |
| WO-2004076453-A1 | NOVEL DIAZABICYCLIC ARYL DERIVATIVES | NEUROSEARCH A/S (DK) | 2004-09-10 | — | — | WO | claimed |
| WO-2004016616-A1 | ARYL-SUBSTITUTED DIAZABICYCLOALKANES AS NICOTINIC ACETYLCHOLINE AGONISTS. | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | claimed |
| US-20100130483-A1 | NOVEL DIAZABICYCLIC ARYL DERIVATIVES | NEUROSEARCH A/S (DK) | 2010-05-27 | — | — | US | disclosed |
| US-7678788-B2 | Diazabicyclic aryl derivatives | NEUROSEARCH A/S (DK) | 2010-03-16 | — | — | US | disclosed |
| EP-1599476-B1 | NOVEL DIAZABICYCLIC ARYL DERIVATIVES | NEUROSEARCH AS (DK) | 2009-10-14 | — | — | EP | disclosed |
| EP-1539764-B1 | ARYL-SUBSTITUTED DIAZABICYCLOALKANES AS NICOTINIC ACETYLCHOLINE AGONISTS. | ASTRAZENECA AB (SE) | 2009-04-29 | — | — | EP | disclosed |
| EP-1539765-B1 | BIARYL DIAZABICYCLOALKANE AMIDES AS NICOTINIC ACETYLCHOLINE AGONISTS | ASTRAZENECA AB (SE) | 2008-12-10 | — | — | EP | disclosed |
| US-20050239774-A1 | Biaryl diazabicycloalkane amides as nicotinic acetylcholine agonists | ASTRAZENECA AB (SE) | 2005-10-27 | — | — | US | disclosed |
| EP-1539764-A1 | ARYL-SUBSTITUTED DIAZABICYCLOALKANES AS NICOTINIC ACETYLCHOLINE AGONISTS. | AstraZeneca AB (SE) | 2005-06-15 | — | — | EP | disclosed |
| EP-1539765-A1 | BIARYL DIAZABICYCLOALKANE AMIDES AS NICOTINIC ACETYLCHOLINE AGONISTS | AstraZeneca AB (SE) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004076453-A1 | NOVEL DIAZABICYCLIC ARYL DERIVATIVES | NEUROSEARCH A/S (DK) | 2004-09-10 | — | — | WO | disclosed |
| WO-2004016617-A1 | BIARYL DIAZABICYCLOALKANE AMIDES AS NICOTINIC ACETYLCHOLINE AGONISTS | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | disclosed |
| WO-2004016616-A1 | ARYL-SUBSTITUTED DIAZABICYCLOALKANES AS NICOTINIC ACETYLCHOLINE AGONISTS. | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130483-A1 | NOVEL DIAZABICYCLIC ARYL DERIVATIVES | CHRNA6, CHRNA10, CHRNA2 | CHRNA7 6/4885CHRNA3 5/4885CHRNB2 8/4885 |
| US-20060148789-A1 | Novel diazabicyclic aryl derivatives | CHRNA6, CHRNA10, CHRNA2 | CHRNA7 6/4885CHRNA3 5/4885CHRNB2 8/4885 |
| US-20050239774-A1 | Biaryl diazabicycloalkane amides as nicotinic acetylcholine agonists | CHRNA1, CHRNB1, CHRNA2 | CHRNA7 6/4885CHRNA3 8/4885CHRNB2 4/4885 |
| US-20060052368-A1 | Aryl-substituted diazabicycloalkanes as nicotinic acetylcholine agonists | CHRNA7, CHRNB1, CHRNA1 | CHRNA7 1/4885CHRNA3 13/4885CHRNB2 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.