Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EED | O75530 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 2/20 | 0.42 |
| ▸ | CHUK | O15111 | 2/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.41 |
| ▸ | ACP1 | P24666 | 3/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3324472 | 1.00 | EED (0.43) | EEDJAK2JAK1JAK3IKBKB | |
| SCHEMBL4238980 | 0.91 | MAP2K1 (0.42) | JAK2JAK1JAK3IKBKBCHUK | |
| SCHEMBL3328810 | 0.90 | MAP2K1 (0.43) | IKBKBCHUKMAP2K1KDM1ASLC6A4 | |
| SCHEMBL3324733 | 0.90 | MAP2K1 (0.43) | IKBKBCHUKMAP2K1KDM1ASLC6A4 | |
| SCHEMBL3323670 | 0.89 | IKBKB (0.43) | JAK2JAK1JAK3IKBKBCHUK | |
| SCHEMBL3324255 | 0.89 | IKBKB (0.43) | JAK2JAK1JAK3IKBKBCHUK | |
| SCHEMBL3325855 | 0.89 | S1PR4 (0.45) | IKBKBCHUKS1PR4MAP2K1SLC6A2 | |
| SCHEMBL3325306 | 0.89 | S1PR4 (0.45) | IKBKBCHUKS1PR4MAP2K1SLC6A2 | |
| SCHEMBL3323336 | 0.89 | IKBKB (0.43) | EEDJAK2JAK1JAK3IKBKB | |
| SCHEMBL3323340 | 0.89 | IKBKB (0.43) | EEDJAK2JAK1JAK3IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100120858-A1 | Piperidine Derivatives | PFIZER INC. | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120858-A1 | Piperidine Derivatives | P2RX5, P2RX7, P2RX1 | EED 1352/4885JAK2 67/4885JAK1 424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.