Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | ALDH1A3 | P47895 | 6/20 | 0.49 |
| ▸ | ALDH3A1 | P30838 | 6/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TACR2 | P21452 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20488818 | 0.88 | ALDH1A3 (0.49) | ALDH1A1ALDH1A3ALDH3A1PTGER4VCAM1 | |
| SCHEMBL2395571 | 0.81 | ALDH1A1 (0.55) | ALDH1A1ALDH1A3ALDH3A1PTGER4VCAM1 | |
| SCHEMBL25229335 | 0.80 | ALDH1A1 (0.53) | ALDH1A1ALDH1A3ALDH3A1PTGER4VCAM1 | |
| SCHEMBL7189747 | 0.79 | ALDH1A1 (0.57) | ALDH1A1ALDH1A3ALDH3A1PTGER4VCAM1 | |
| SCHEMBL15574149 | 0.79 | ALDH1A1 (0.40) | ALDH1A1ALDH1A3ALDH3A1PTGER4TSHR | |
| SCHEMBL13044803 | 0.78 | ALDH1A1 (0.55) | ALDH1A1ALDH1A3ALDH3A1VCAM1HSD17B10 | |
| SCHEMBL11374196 | 0.78 | ALDH1A1 (0.55) | ALDH1A1ALDH1A3ALDH3A1VCAM1HSD17B10 | |
| SCHEMBL21773462 | 0.77 | ALDH1A1 (0.50) | ALDH1A1ALDH1A3ALDH3A1PTGER4VCAM1 | |
| SCHEMBL3240034 | 0.77 | ALDH1A1 (0.50) | ALDH1A1ALDH1A3ALDH3A1VCAM1HSD17B10 | |
| SCHEMBL13911296 | 0.77 | DDR1 (0.48) | TSHRDDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137300-A1 | Indolizine Acetic Acid Derivatives as CRTH2 Antagonists | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-06-03 | — | — | US | disclosed |
| CN-101678009-A | Indolizine acetic acid derivatives as CRTH2 antagonists | ARGENTA DISCOVERY LTD | 2010-03-24 | — | — | CN | disclosed |
| EP-2136804-A1 | INDOLIZINE ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | Argenta Oral Therapeutics Limited (GB) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008113965-A1 | INDOLIZINE ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | ARGENTA DISCOVERY LIMITED (GB) | 2008-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137300-A1 | Indolizine Acetic Acid Derivatives as CRTH2 Antagonists | HRH1, HRH4, HRH2 | ALDH1A1 744/4885ALDH1A3 824/4885ALDH3A1 849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.