Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA known ✓ | P35790 | 9/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1461850 | 0.79 | KDM4E (0.68) | CHKAKDM4ENPC1RAB9A | |
| SCHEMBL1363019 | 0.77 | KDM4E (0.69) | CHKAKDM4ENPC1MITFALDH1A1 | |
| SCHEMBL4625936 | 0.77 | KDM4E (0.44) | CHKAKDM4ENPC1ALDH1A1HTT | |
| SCHEMBL10136900 | 0.76 | KDM4E (0.80) | CHKAKDM4ENPC1MITFALDH1A1 | |
| Bromide SCHEMBL21436708 | 0.76 | CHKA (0.50) | CHKAKDM4ENPC1MITFALDH1A1 | |
| Water SCHEMBL14740255 | 0.72 | CHKA (0.88) | CHKA | |
| Hydrochloric Acid SCHEMBL17845876 | 0.72 | KDM4E (0.51) | CHKAKDM4ENPC1MITFALDH1A1 | |
| Hydrochloric Acid SCHEMBL10548962 | 0.72 | KDM4E (0.51) | CHKAKDM4ENPC1MITFALDH1A1 | |
| Bromide SCHEMBL17075096 | 0.72 | CHKA (0.47) | CHKAKDM4ENPC1MITFALDH1A1 | |
| Bromide SCHEMBL18334837 | 0.72 | CHKA (0.58) | CHKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2607431-B1 | Cyanine dye compounds | LIFE TECHNOLOGIES CORP (US) | 2016-08-24 | — | — | EP | disclosed |
| EP-1720944-B1 | CYANINE DYE COMPOUNDS | LIFE TECHNOLOGIES CORP (US) | 2013-07-17 | — | — | EP | disclosed |
| EP-2607431-A1 | Cyanine dye compounds | Life Technologies Corporation (US) | 2013-06-26 | — | — | EP | disclosed |
| US-7842811-B2 | Cyanine dye compounds | Life Technologies Corporation (US) | 2010-11-30 | — | — | US | disclosed |
| US-20100120051-A1 | CYANINE DYE COMPOUNDS | Life Technologies Corporation (US) | 2010-05-13 | — | — | US | disclosed |
| US-7655409-B2 | Have negatively charged substituent for fluorescent staining of DNA; used to distinguish DNA present in a sample from RNA | Life Technologies Corporation (US) | 2010-02-02 | — | — | US | disclosed |
| US-20090047683-A1 | CYANINE DYE COMPOUNDS | INVITROGEN CORPORATION (US) | 2009-02-19 | — | — | US | disclosed |
| US-7446202-B2 | Cyanine dye compounds | MOLECULAR PROBES, INC. (US) | 2008-11-04 | — | — | US | disclosed |
| EP-1720944-A2 | CYANINE DYE COMPOUNDS | Molecular Probes Inc. (US) | 2006-11-15 | — | — | EP | disclosed |
| US-20050214810-A1 | Cyanine dye compounds | MOLECULAR PROBES, INC. | 2005-09-29 | — | — | US | disclosed |
| WO-2005056689-A2 | CYANINE DYE COMPOUNDS | MOLECULAR PROBES, INC. (US) | 2005-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050214810-A1 | Cyanine dye compounds | POLL, XPA, DUT | CHKA 803/4885KDM4E 801/4885NPC1 2613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.