Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA known ✓ | P35790 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1363019 | 0.98 | KDM4E (0.69) | KDM4ELMNANPC1RAB9APOLB | |
| Bromide SCHEMBL6246487 | 0.85 | KDM4E (0.63) | KDM4ELMNANPC1RAB9APOLB | |
| SCHEMBL12330785 | 0.85 | KDM4E (0.55) | KDM4ELMNANPC1RAB9APOLB | |
| SCHEMBL12330996 | 0.85 | KDM4E (0.58) | KDM4ELMNANPC1RAB9APOLB | |
| Bromide SCHEMBL6245928 | 0.81 | NPC1 (0.62) | KDM4ELMNANPC1RAB9APOLB | |
| Bromide SCHEMBL2482814 | 0.80 | KDM4E (0.59) | KDM4ELMNANPC1RAB9APOLB | |
| SCHEMBL9934703 | 0.80 | KDM4E (0.58) | KDM4ELMNANPC1RAB9APOLB | |
| Bromide SCHEMBL3324489 | 0.79 | CHKA (0.54) | KDM4ENPC1RAB9ACHKA | |
| SCHEMBL1476988 | 0.78 | KDM4E (0.57) | KDM4ELMNANPC1RAB9APOLB | |
| SCHEMBL23230144 | 0.77 | NPC1 (0.52) | KDM4ELMNANPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2982245-B1 | CYANINE DYES FOR LABELING OF TARGET MOLECULES, IDENTIFICATION OF ORGANELLES AND OTHER APPLICATIONS | ENZO LIFE SCIENCES INC (US) | 2018-08-08 | — | — | EP | disclosed |
| EP-1885718-B1 | FLUORESCENT CHEMICAL COMPOUNDS HAVING HIGH SELECTIVITY FOR DOUBLE STRANDED DNA, AND METHODS FOR THEIR USE | LIFE TECHNOLOGIES CORP (US) | 2017-03-15 | — | — | EP | disclosed |
| EP-2607431-B1 | Cyanine dye compounds | LIFE TECHNOLOGIES CORP (US) | 2016-08-24 | — | — | EP | disclosed |
| US-9366676-B2 | Fluorescent chemical compounds having high selectivity for double stranded DNA, and methods for their use | Life Technologies Corporation (US) | 2016-06-14 | — | — | US | disclosed |
| EP-2982245-A1 | LABELING OF TARGET MOLECULES, IDENTIFICATION OF ORGANELLES AND OTHER APPLICATIONS, NOVEL COMPOSITIONS, METHODS AND KITS | Enzo Life Sciences, Inc. (US) | 2016-02-10 | — | — | EP | disclosed |
| US-20150316558-A1 | Fluorescent Chemical Compounds Having High Selectivity for Double Stranded DNA, and Methods for Their Use | MOLECULAR PROBES, INC. | 2015-11-05 | — | — | US | disclosed |
| EP-2381783-B1 | LABELING OF TARGET MOLECULES, IDENTIFICATION OF ORGANELLES AND OTHER APPLICATIONS, NOVEL COMPOSITIONS, METHODS AND KITS | ENZO LIFE SCIENCES INC (US) | 2015-09-02 | — | — | EP | disclosed |
| US-9115397-B2 | Fluorescent chemical compounds having high selectivity for double stranded DNA, and methods for their use | Life Technologies Corporation (US) | 2015-08-25 | — | — | US | disclosed |
| US-20150004597-A1 | Fluorescent Chemical Compounds Having High Selectivity for Double Stranded DNA, and Methods for Their Use | LIFE TECHNOLOGIES CORP (US) | 2015-01-01 | — | — | US | disclosed |
| US-8865904-B2 | Fluorescent chemical compounds having high selectivity for double stranded DNA, and methods for their use | Life Technologies Corporation (US) | 2014-10-21 | — | — | US | disclosed |
| WO-2006124816-A1 | FLUORESCENT CHEMICAL COMPOUNDS HAVING HIGH SELECTIVITY FOR DOUBLE STRANDED DNA, AND METHODS FOR THEIR USE | MOLECULAR PROBES, INC. (US) | 2006-11-23 | — | — | WO | disclosed |
| EP-1720944-A2 | CYANINE DYE COMPOUNDS | Molecular Probes Inc. (US) | 2006-11-15 | — | — | EP | disclosed |
| US-20050214810-A1 | Cyanine dye compounds | MOLECULAR PROBES, INC. | 2005-09-29 | — | — | US | disclosed |
| EP-1303751-B1 | DYES AND METHODS OF DETECTION OF NUCLEIC ACID IN IMMATURE RED BLOOD CELLS | COULTER INT CORP (US) | 2005-08-10 | — | — | EP | disclosed |
| WO-2005056689-A2 | CYANINE DYE COMPOUNDS | MOLECULAR PROBES, INC. (US) | 2005-06-23 | — | — | WO | disclosed |
| EP-1303751-A4 | DYES AND METHODS OF DETECTION OF NUCLEIC ACID IN IMMATURE RED BLOOD CELLS | COULTER INT CORP (US) | 2003-05-28 | — | — | EP | disclosed |
| EP-1303751-A1 | DYES AND METHODS OF DETECTION OF NUCLEIC ACID IN IMMATURE RED BLOOD CELLS | Coulter International Corp. (US) | 2003-04-23 | — | — | EP | disclosed |
| US-6551831-B2 | Detection of nucleic acids in red blood cells by flow cytometry by employing fluorescent, nucleic acid binidng cyanine dye | COULTER INTERNATIONAL CORP. | 2003-04-22 | — | — | US | disclosed |
| US-20020037589-A1 | Dyes and methods of detection of nucleic acid in immature red blood cells | COULTER INTERNATIONAL CORP. | 2002-03-28 | — | — | US | disclosed |
| WO-2001086264-A1 | DYES AND METHODS OF DETECTION OF NUCLEIC ACID IN IMMATURE RED BLOOD CELLS | COULTER INTERNATIONAL CORP. (US) | 2001-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050214810-A1 | Cyanine dye compounds | POLL, XPA, DUT | CHKA 803/4885KDM4E 801/4885LMNA 85/4885 |
| US-20150316558-A1 | Fluorescent Chemical Compounds Having High Selectivity for Double Stranded DNA, and Methods for Their Use | POLRMT, DNA2, NSUN2 | CHKA 2846/4885KDM4E 2506/4885LMNA 473/4885 |
| US-20150004597-A1 | Fluorescent Chemical Compounds Having High Selectivity for Double Stranded DNA, and Methods for Their Use | POLRMT, DNA2, NSUN2 | CHKA 2846/4885KDM4E 2506/4885LMNA 473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.