Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | CCR9 | P51686 | 7/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ITGA1 | P56199 | 2/20 | 0.48 |
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
| ▸ | ACLY | P53396 | 1/20 | 0.46 |
| ▸ | SLC10A6 | Q3KNW5 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2533283 | 0.83 | LMNA (0.64) | LMNAHTTCCR9MAPTALDH1A1 | |
| SCHEMBL16715960 | 0.83 | LMNA (0.71) | LMNAHTTCCR9MAPTALDH1A1 | |
| SCHEMBL2528724 | 0.83 | LMNA (0.64) | LMNAHTTCCR9MAPTALDH1A1 | |
| SCHEMBL2528982 | 0.83 | ITGA1 (0.69) | LMNAHTTCCR9MAPTALDH1A1 | |
| SCHEMBL2528312 | 0.83 | LMNA (0.67) | LMNAHTTCCR9MAPTALDH1A1 | |
| SCHEMBL27979 | 0.81 | LMNA (0.83) | LMNAHTTCCR9MAPTALDH1A1 | |
| SCHEMBL12032387 | 0.81 | LMNA (0.64) | LMNAHTTCCR9MAPTALDH1A1 | |
| SCHEMBL27681 | 0.81 | ALDH1A1 (0.61) | LMNAHTTCCR9MAPTALDH1A1 | |
| SCHEMBL28006 | 0.80 | LMNA (0.86) | LMNAHTTCCR9MAPTALDH1A1 | |
| SCHEMBL28792 | 0.80 | LMNA (0.62) | LMNAHTTCCR9MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402310-A1 | CCR9 inhibitors and methods of use thereof | Millennium Pharmaceuticals, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |
| EP-2402309-A1 | CCR9 inhibitors and methods of use thereof | Millennium Pharmaceuticals, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |
| EP-2399903-A1 | CCR9 INHIBITORS AND METHODS OF USE THEREOF | Millennium Pharmaceuticals, Inc. (US) | 2011-12-28 | — | — | EP | disclosed |