Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 6/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 3/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3324795 | 0.93 | HTR1A (0.43) | IRAK4SLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL3324983 | 0.93 | HTR1A (0.43) | IRAK4SLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL3324787 | 0.93 | HTR1A (0.43) | IRAK4SLC6A2SLC6A4SLC6A3HTR1A | |
| Oxalic Acid SCHEMBL3321313 | 0.81 | KDM4E (0.44) | SLC6A2SLC6A4SLC6A3HTR1AKDM4E | |
| Oxalic Acid SCHEMBL3322954 | 0.81 | IRAK4 (0.44) | IRAK4SLC6A2SLC6A4SLC6A3KDM4E | |
| Oxalic Acid SCHEMBL3325165 | 0.81 | KDM4E (0.45) | SLC6A2SLC6A4SLC6A3KDM4E | |
| SCHEMBL23582850 | 0.77 | IRAK4 (0.51) | IRAK4SLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL23582852 | 0.77 | IRAK4 (0.51) | IRAK4SLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL3325931 | 0.75 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3HTR1AADRA2A | |
| SCHEMBL3325927 | 0.75 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100120858-A1 | Piperidine Derivatives | PFIZER INC. | 2010-05-13 | — | — | US | disclosed |
| EP-2066630-A1 | PIPERIDINE DERIVATIVES | Pfizer Products Incorporated (US) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008023258-A1 | PIPERIDINE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2008-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120858-A1 | Piperidine Derivatives | P2RX5, P2RX7, P2RX1 | SLC6A4 1898/4885IRAK4 1593/4885SLC6A2 2609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.