SCHEMBL3326210

SCHEMBL3326210

CCCCC(C=O)NC(=O)C(CC(C)C)NC(=O)C(N)CC(C)C

nearest known ligand 0.53

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CTSK P43235 13/20 0.53
SLC15A1 P46059 1/20 0.42
CTSL P07711 4/20 0.41
CTSB P07858 4/20 0.41
DPP4 P27487 4/20 0.40
DPP9 Q86TI2 4/20 0.40
DPP7 Q9UHL4 4/20 0.40
DPP8 Q6V1X1 3/20 0.40
CTSH P09668 2/20 0.39
CTSS P25774 1/20 0.38
MMP3 P08254 1/20 0.37
MMP9 P14780 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4775289 1.00 CTSK (0.53) CTSKSLC15A1CTSLCTSBDPP4
SCHEMBL3326212 1.00 CTSK (0.53) CTSKSLC15A1CTSLCTSBDPP4
SCHEMBL4775282 1.00 CTSK (0.53) CTSKSLC15A1CTSLCTSBDPP4
SCHEMBL6031204 0.93 CTSK (0.59) CTSKSLC15A1CTSLCTSBDPP4
SCHEMBL8003112 0.93 CTSK (0.59) CTSKSLC15A1CTSLCTSBDPP4
SCHEMBL9572289 0.93 CTSK (0.59) CTSKSLC15A1CTSLCTSBDPP4
SCHEMBL4226584 0.92 CTSK (0.43) CTSKSLC15A1CTSLCTSBDPP4
SCHEMBL4226580 0.92 CTSK (0.43) CTSKSLC15A1CTSLCTSBDPP4
SCHEMBL1783728 0.86 CTSK (0.56) CTSKCTSLCTSBCTSHCTSS
SCHEMBL14876797 0.86 CTSK (0.56) CTSKCTSLCTSBCTSHCTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024018245-A1 USE OF CALPAIN INHIBITORS FOR THE TREATMENT OF THE DIABETIC KIDNEY DISEASE INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2024-01-25 WO disclosed
EP-3801581-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF MUSCLE CONTRACTURES Children's Hospital Medical Center (US) 2021-04-14 EP disclosed
EP-2934573-A1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR PREVENTION OF AGING-RELATED LESIONS Assistance Publique-Hôpitaux de Paris (FR) 2015-10-28 EP disclosed
WO-2015032841-A2 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR PREVENTION OR TREATMENT OF TH17 MEDIATED DISEASE INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2015-03-12 WO disclosed
WO-2014096087-A1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR PREVENTION OF AGING-RELATED LESIONS INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2014-06-26 WO disclosed
US-20100129343-A1 Use Of A Compound For Enhancing The Expression Of Membrane Proteins On The Cell Surface AXENTIS PHARMA AG (CH) 2010-05-27 US disclosed
EP-2073849-A2 METHODS AND COMPOSITIONS FOR GENE THERAPY CANJI, Inc. (US) 2009-07-01 EP disclosed
US-20080220416-A1 Compositions for Inhibiting Cell Growth and Inducing Apoptosis in Cancer Cells and Methods of Use Thereof THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOI (US) 2008-09-11 US disclosed
WO-2008060356-A2 METHODS AND COMPOSITIONS FOR GENE THERAPY CANJI, INC. (US) 2008-05-22 WO disclosed
US-20070218043-A1 Use of a compound for enhancing the expression of membrane proteins on the cell surface BIODEVELOPS PHARMA ENTWICKLUNG GMBH 2007-09-20 US disclosed
EP-1771194-A2 USE OF A DEUBIQUITINATING COMPOUND FOR ENHANCING THE EXPRESSION OF MEMBRANE PROTEINS ON THE CELL SURFACE Biodevelops Pharma Entwicklung GmbH (AT) 2007-04-11 EP disclosed
EP-1704250-A2 METHODS FOR PREDICTING AND OVERCOMING RESISTANCE TO CHEMOTHERAPY IN OVARIAN CANCER AND FOR PREDICTING COLON CANCER OCCURRENCE THE PENN STATE RESEARCH FOUNDATION (US) 2006-09-27 EP disclosed
WO-2006002453-A2 USE OF A DEUBIQUITINATING COMPOUND FOR ENHANCING THE EXPRESSION OF MEMBRANE PROTEINS ON THE CELL SURFACE BIODEVELOPS PHARMA ENTWICKLUNG GMBH (AT) 2006-01-12 WO disclosed
US-20060008454-A1 Use of a compound for enhancing the expression of membrane proteins on the cell surface DR. HELMUT BRUNAR 2006-01-12 US disclosed
WO-2006001956-A2 COMPOSITIONS FOR INHIBITING CELL GROWTH AND INDUCING APOPTOSIS IN CANCER CELLS AND METHODS OF USE THEREOF THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2006-01-05 WO disclosed
WO-2005066371-A2 METHODS FOR PREDICTING AND OVERCOMING RESISTANCE TO CHEMOTHERAPY IN OVARIAN CANCER AND FOR PREDICTING COLON CANCER OCCURRENCE THE PENN STATE RESEARCH FOUNDATION (US) 2005-07-21 WO disclosed
WO-2000029573-A2 ADENOVIRAL VECTORS CANJI, INC. (US) 2000-05-25 WO disclosed
EP-0995757-A2 Bivalent inhibitors of the proteasome Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2000-04-26 EP disclosed
WO-1997032605-A1 CYTOMEGALOVIRUS NUCLEIC ACIDS ENCODING PROTEINS HAVING NORMAL OR ALTERED CLASS I MHC BINDING AND TREATMENT OF DISEASES MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1997-09-12 WO disclosed