Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFSF11 | O14788 | 1/20 | 0.63 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | JUN | P05412 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 2/20 | 0.43 |
| ▸ | AR | P10275 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14597441 | 0.89 | CFD (0.48) | TNFSF11LCKFYNTSHRALDH1A1 | |
| SCHEMBL27602532 | 0.85 | TNFSF11 (0.83) | TNFSF11TSHRNR3C1ALDH1A1JUN | |
| SCHEMBL21723164 | 0.85 | TNFSF11 (0.83) | TNFSF11TSHRNR3C1ALDH1A1JUN | |
| SCHEMBL8928654 | 0.85 | TNFSF11 (0.83) | TNFSF11TSHRNR3C1ALDH1A1JUN | |
| SCHEMBL3993973 | 0.80 | TNFSF11 (0.54) | TNFSF11TSHRNR3C1ALDH1A1CYP3A4 | |
| SCHEMBL20208856 | 0.79 | NCEH1 (0.51) | TNFSF11TSHRALDH1A1PTGS1HPGD | |
| SCHEMBL19683379 | 0.79 | NCEH1 (0.51) | TNFSF11TSHRALDH1A1PTGS1HPGD | |
| SCHEMBL8649089 | 0.79 | PRKDC (0.59) | TNFSF11LCKFYNTSHRNR3C1 | |
| SCHEMBL6535987 | 0.79 | PRKDC (0.74) | TNFSF11LCKFYNTSHRALDH1A1 | |
| SCHEMBL15680262 | 0.78 | LCK (0.61) | TNFSF11LCKFYNTSHRNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148865-B1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | GENENTECH INC (US) | 2017-05-17 | — | — | EP | disclosed |
| US-20100137394-A1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | GRENENTECH, INC. (US) | 2010-06-03 | — | — | US | disclosed |
| EP-2148865-A1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | Genentech, Inc. (US) | 2010-02-03 | — | — | EP | disclosed |
| WO-2008137408-A1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | GENENTECH, INC. (US) | 2008-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137394-A1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | WNT1, WNT3A, CTNNB1 | TNFSF11 4072/4885LCK 1874/4885FYN 1824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.