Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 6/20 | 0.43 |
| ▸ | GSR | P00390 | 8/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10550837 | 1.00 | ALDH1A1 (0.59) | ALDH1A1MAPTBCHEGSRCA2 | |
| SCHEMBL10741301 | 0.81 | ALDH1A1 (0.56) | ALDH1A1MAPTBCHEGSRCA2 | |
| Isosorbide Dinitrate SCHEMBL9439417 | 0.76 | ALDH1A1 (1.00) | ALDH1A1MAPTBCHEGSRCA2 | |
| Isosorbide Dinitrate SCHEMBL1553054 | 0.76 | ALDH1A1 (1.00) | ALDH1A1MAPTBCHEGSRCA2 | |
| Isosorbide Dinitrate SCHEMBL19528695 | 0.76 | ALDH1A1 (1.00) | ALDH1A1MAPTBCHEGSRCA2 | |
| Isosorbide Dinitrate SCHEMBL8253 | 0.76 | ALDH1A1 (1.00) | ALDH1A1MAPTBCHEGSRCA2 | |
| Isosorbide Dinitrate SCHEMBL29532755 | 0.76 | ALDH1A1 (1.00) | ALDH1A1MAPTBCHEGSRCA2 | |
| Isosorbide Dinitrate SCHEMBL309369 | 0.76 | ALDH1A1 (1.00) | ALDH1A1MAPTBCHEGSRCA2 | |
| SCHEMBL10699039 | 0.74 | ALDH1A1 (0.47) | ALDH1A1MAPTBCHEGSR | |
| Isosorbide Dinitrate SCHEMBL714959 | 0.74 | ALDH1A1 (0.95) | ALDH1A1MAPTBCHEGSRCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0290885-A2 | 1,4:3,6-Dianhydrosorbitol 2-mono-nitrate and 5-mononitrate esters, a process for the preparation thereof and pharmaceutical compositions therefrom | CHIESI FARMACEUTICI S.p.A. (IT) | 1988-11-17 | — | — | EP | claimed |
| EP-1948183-B1 | COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF HEART DISEASE AND METHODS OF USING SAME | UNIV DUKE (US) | 2013-12-18 | — | — | EP | disclosed |
| US-20100137284-A1 | Compositions for the Treatment and Prevention of Heart Disease and Methods of Using Same | STAMLER, JONATHAN S. | 2010-06-03 | — | — | US | disclosed |
| EP-1948183-A1 | COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF HEART DISEASE AND METHODS OF USING SAME | Duke University (US) | 2008-07-30 | — | — | EP | disclosed |
| US-20070208041-A1 | Compositions for the treatment and prevention of heart disease and methods of using same | PLATINUM LONG TERM GROWTH VI, LLC | 2007-09-06 | — | — | US | disclosed |
| WO-2007044910-A1 | COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF HEART DISEASE AND METHODS OF USING SAME | DUKE UNIVERSITY (US) | 2007-04-19 | — | — | WO | disclosed |
| US-4956384-A | CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS, VASODILATOR AGENTS, ANGINA | CHIESI FARMACEUTICI S.P.A. (IT) | 1990-09-11 | — | — | US | disclosed |
| EP-0290885-A2 | 1,4:3,6-Dianhydrosorbitol 2-mono-nitrate and 5-mononitrate esters, a process for the preparation thereof and pharmaceutical compositions therefrom | CHIESI FARMACEUTICI S.p.A. (IT) | 1988-11-17 | — | — | EP | disclosed |