Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.39 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.39 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3330232 | 0.88 | ALDH1A1 (0.53) | ITGB3ITGA2BALDH1A1SMN1; SMN2CHRM1 | |
| SCHEMBL4027409 | 0.78 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2CHRM1CHRM3EPHX2 | |
| SCHEMBL1143597 | 0.76 | MEN1 (0.58) | ALDH1A1CES2CES1TAS1R3TAS1R1 | |
| SCHEMBL20491195 | 0.75 | KMT2A (0.51) | ITGB3ITGA2BALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL20491395 | 0.75 | CES2 (0.52) | ALDH1A1CES2CES1DPP4MEN1 | |
| SCHEMBL30298669 | 0.72 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2CHRM1CHRM3EPHX2 | |
| SCHEMBL23014274 | 0.72 | KMT2A (0.49) | ITGB3ITGA2BALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL11667876 | 0.71 | NPC1 (0.50) | ALDH1A1SMN1; SMN2GNAI3GNAO1GNAI1 | |
| SCHEMBL15732620 | 0.71 | POLB (0.43) | ITGB3ITGA2BEPHX2KMT2AHSD11B1 | |
| SCHEMBL15732637 | 0.70 | NOTUM (0.45) | ITGB3ITGA2BEPHX2TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100120801-A1 | AKT AND P70 S6 KINASE INHIBITORS | ELI LILLY AND COMPANY | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120801-A1 | AKT AND P70 S6 KINASE INHIBITORS | RPS6KA6, RPS6KA1, MTOR | ITGB3 3894/4885ITGA2B 3448/4885ALDH1A1 4352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.