Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.30 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.30 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | GPR183 | P32249 | 1/20 | 0.30 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.30 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.30 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3409486 | 0.84 | — | — | |
| SCHEMBL28503876 | 0.84 | — | — | |
| Tromethamine SCHEMBL2382360 | 0.78 | MEN1 (0.46) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL7091150 | 0.73 | MEN1 (0.56) | MEN1LMNAKMT2A | |
| SCHEMBL5053381 | 0.71 | TSHR (0.36) | — | |
| SCHEMBL598712 | 0.67 | MEN1 (0.53) | MEN1LMNAKMT2ATNNC1SGPL1 | |
| SCHEMBL1170716 | 0.67 | — | — | |
| SCHEMBL28558947 | 0.67 | TSHR (0.33) | — | |
| Tromethamine SCHEMBL7642116 | 0.67 | MEN1 (0.42) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL11249726 | 0.66 | MEN1 (0.53) | MEN1LMNAKMT2ATNNC1SGPL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100121011-A1 | 1-BUTENE PROPYLENE COPOLYMER COMPOSITIONS | BASELL POLYOLEFINE GMBH (DE) | 2010-05-13 | — | — | US | disclosed |