Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL2382360 | 0.80 | MEN1 (0.46) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL7567125 | 0.79 | LMNA (0.67) | MEN1LMNAKMT2ATSHRALDH1A1 | |
| Tromethamine SCHEMBL7936297 | 0.76 | MEN1 (0.53) | MEN1LMNAKMT2ATSHRALDH1A1 | |
| Tromethamine SCHEMBL7193959 | 0.75 | MEN1 (0.83) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL28216031 | 0.75 | MEN1 (0.83) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL17484 | 0.74 | MEN1 (1.00) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL975 | 0.74 | — | — | |
| Tromethamine SCHEMBL3696191 | 0.74 | — | — | |
| Tromethamine SCHEMBL8334055 | 0.74 | LMNA (0.59) | MEN1LMNAKMT2ATSHRALDH1A1 | |
| Tromethamine SCHEMBL9363390 | 0.74 | MEN1 (0.59) | MEN1LMNAKMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0914323-B1 | METALLOCENES AND CATALYSTS FOR POLYMERIZATION OF OLEFINS | BASELL POLYOLEFINE GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |
| US-6268518-B1 | AS POLYMERIZATION CATALYSTS FOR POLYMERIZATION OF OLEFINS | MONTELL TECHNOLOGY COMPANY B.V. (NL) | 2001-07-31 | — | — | US | disclosed |
| EP-0914323-A1 | METALLOCENES AND CATALYSTS FOR POLYMERIZATION OF OLEFINS | Montell Technology Company B.V. (NL) | 1999-05-12 | — | — | EP | disclosed |
| WO-1998043989-A1 | METALLOCENES AND CATALYSTS FOR POLYMERIZATION OF OLEFINS | MONTELL TECHNOLOGY COMPANY B.V. (NL) | 1998-10-08 | — | — | WO | disclosed |