Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.63 |
| ▸ | MTNR1A | P48039 | 14/20 | 0.62 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.59 |
| ▸ | HTR2C | P28335 | 1/20 | 0.59 |
| ▸ | HTR2B | P41595 | 1/20 | 0.59 |
| ▸ | NQO2 | P16083 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1882845 | 0.87 | HTR2A (0.68) | HTR2AMTNR1AMTNR1BHTR2CHTR2B | |
| SCHEMBL6856603 | 0.86 | MTNR1A (0.59) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL12013659 | 0.84 | HTR2A (0.65) | HTR2AMTNR1AMTNR1BHTR2CHTR2B | |
| SCHEMBL8012835 | 0.84 | MTNR1A (0.71) | HTR2AMTNR1AMTNR1BHTR2CHTR2B | |
| SCHEMBL6856426 | 0.83 | MTNR1A (0.50) | HTR2AMTNR1AMTNR1B | |
| SCHEMBL3279789 | 0.83 | HTR2A (0.63) | HTR2AMTNR1AMTNR1BHTR2CHTR2B | |
| SCHEMBL12550704 | 0.83 | HTR2A (0.63) | HTR2AMTNR1AMTNR1BHTR2CHTR2B | |
| SCHEMBL28193568 | 0.83 | HTR2A (0.63) | HTR2AMTNR1AMTNR1BHTR2CHTR2B | |
| SCHEMBL1897589 | 0.83 | HTR2A (0.63) | HTR2AMTNR1AMTNR1BHTR2CHTR2B | |
| SCHEMBL16797976 | 0.82 | HTR2A (0.55) | HTR2AMTNR1AMTNR1BHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104230754-B | A kind of synthetic method of (7-methoxy-1-naphthyl) acetonitrile | ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2017-01-04 | — | — | CN | disclosed |
| CN-104230754-A | Synthetic method for 7-methoxy-1-naphthylacetonitrile | UNIV ZHEJIANG SCIENCES | 2014-12-24 | — | — | CN | disclosed |
| EP-2703383-A1 | Process for the preparation of agomelatine | Procos S.p.A. (IT) | 2014-03-05 | — | — | EP | disclosed |
| EP-2176214-B1 | NOVEL METHOD FOR THE SYNTHESIS OF (7-METHOXY-1-NAPHTHYL)ACETONITRILE AND APPLICATION IN THE SYNTHESIS OF AGOMELATINE | SERVIER LAB (FR) | 2014-03-05 | — | — | EP | disclosed |
| EP-2176214-B1 | NOVEL METHOD FOR THE SYNTHESIS OF (7-METHOXY-1-NAPHTHYL)ACETONITRILE AND APPLICATION IN THE SYNTHESIS OF AGOMELATINE | SERVIER LAB (FR) | 2014-03-05 | — | — | EP | disclosed |
| CN-101772484-B | Novel method for the synthesis of (7-methoxy-l-naphthyl)acetonitrile and application in the synthesis of agomelatine | SERVIER LAB | 2013-09-18 | — | — | CN | disclosed |
| US-8436206-B2 | Process for the synthesis of (7-methoxy-1-naphthyl) acetonitrile and application in the synthesis of agomelatine | LES LABORATOIRES SERVIER (FR) | 2013-05-07 | — | — | US | disclosed |
| US-8436206-B2 | Process for the synthesis of (7-methoxy-1-naphthyl) acetonitrile and application in the synthesis of agomelatine | LES LABORATOIRES SERVIER (FR) | 2013-05-07 | — | — | US | disclosed |
| US-20120330062-A1 | PROCESS FOR THE SYNTHESIS OF (7-METHOXY-1-NAPHTHYL) ACETONITRILE AND APPLICATION IN THE SYNTHESIS OF AGOMELATINE | LES LABORATOIRES SERVIER (FR) | 2012-12-27 | — | — | US | disclosed |
| US-8252951-B2 | Process for the synthesis of (methoxy-1-naphthyl) acetonitrile and application in the synthesis of agomelatine | LES LABORATOIRES SERVIER (FR) | 2012-08-28 | — | — | US | disclosed |
| WO-2009053545-A2 | NOVEL METHOD FOR THE SYNTHESIS OF (7-METHOXY-L-NAPHTHYL)ACETONITRILE AND APPLICATION IN THE SYNTHESIS OF AGOMELATINE | LES LABORATOIRES SERVIER (FR) | 2009-04-30 | — | — | WO | disclosed |
| WO-2009053545-A2 | NOVEL METHOD FOR THE SYNTHESIS OF (7-METHOXY-L-NAPHTHYL)ACETONITRILE AND APPLICATION IN THE SYNTHESIS OF AGOMELATINE | LES LABORATOIRES SERVIER (FR) | 2009-04-30 | — | — | WO | disclosed |
| US-6583319-B1 | Treating or preventing melatoninergic disorders | LES LABORATOIRES SERVIER (FR) | 2003-06-24 | — | — | US | disclosed |
| EP-0994102-B1 | Cyclic derivatives with a cycloalkylenic chain, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-03-19 | — | — | EP | disclosed |
| EP-0994102-A1 | Cyclic derivatives with a cycloalkylenic chain, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-04-19 | — | — | EP | disclosed |
| CN-1048720-C | New o-arylmethyl-N-(thio)acylhydroxylamines, process for preparing them and pharmaceutical compositions containing them | ADIR (FR) | 2000-01-26 | — | — | CN | disclosed |
| EP-0709371-B1 | O-arylmethyl N-(thio)acyl hydroxylamines as ligands for the melatonine receptors, their processes of preparation and the pharmaceutical compositions containing them | ADIR (FR) | 1998-05-06 | — | — | EP | disclosed |
| US-5612368-A | SKIN DISORDERS, MELATONINERGIC SYSTEMS, ANTIARRHYTHMIA AGENTS OR ANTIISCHEMIC AGENTS | ADIR ET COMPAGNIE (FR) | 1997-03-18 | — | — | US | disclosed |
| CN-1127247-A | New o-arylmethyl-N-(thio)acylhydroxylamines, process for preparing them and pharmaceutical compositions containing them | ADIR (FR) | 1996-07-24 | — | — | CN | disclosed |
| EP-0709371-A1 | O-arylmethyl N-(thio)acyl hydroxylamines as ligands for the melatonine receptors, their processes of preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-05-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120330062-A1 | PROCESS FOR THE SYNTHESIS OF (7-METHOXY-1-NAPHTHYL) ACETONITRILE AND APPLICATION IN THE SYNTHESIS OF AGOMELATINE | COMT, PNMT, TPH1 | HTR2A 93/4885MTNR1A 62/4885MTNR1B 86/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.