Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL332098 | 0.85 | ALOX5 (0.46) | ALOX5MAPTRAB9ACYP2C19TDP1 | |
| SCHEMBL332097 | 0.85 | ALOX5 (0.46) | ALOX5MAPTRAB9ACYP2C19TDP1 | |
| SCHEMBL332226 | 0.85 | ALOX5 (0.66) | ALOX5MAPTNPC1RAB9ACYP2C9 | |
| SCHEMBL333261 | 0.81 | ALOX5 (0.58) | ALOX5MAPTNPC1RAB9ACYP2C9 | |
| SCHEMBL332786 | 0.80 | ALOX5 (0.61) | ALOX5PIK3CD | |
| SCHEMBL7654887 | 0.78 | ALOX5 (0.68) | ALOX5ALDH1A1HRH3PIK3CDLMNA | |
| SCHEMBL13201380 | 0.76 | ALOX5 (0.58) | ALOX5MAPTNPC1RAB9ACYP2C9 | |
| SCHEMBL333542 | 0.75 | ALOX5 (0.56) | ALOX5MAPTALDH1A1HRH3PIK3CD | |
| SCHEMBL2702973 | 0.72 | ALOX5 (0.50) | ALOX5TDP1ALDH1A1HRH3PIK3CD | |
| SCHEMBL332424 | 0.71 | ALOX5 (0.62) | ALOX5HRH3PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8097733-B2 | Pyrazole derivatives as 5-LO-inhibitors | PFIZER INC. (US) | 2012-01-17 | — | — | US | disclosed |
| US-20090227634-A1 | Pyrazole Derivatives as 5-LO-Inhibitors | PFIZER INC. | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227634-A1 | Pyrazole Derivatives as 5-LO-Inhibitors | ALOX5, ALOX15, CYP3A5 | ALOX5 1/4885MAPT 4364/4885NPC1 1623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.