Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 8/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL332226 | 0.84 | ALOX5 (0.66) | ALOX5NPC1MAPTCYP2C9CYP2C19 | |
| SCHEMBL7654887 | 0.84 | ALOX5 (0.68) | ALOX5ALDH1A1HRH3PIK3CDLMNA | |
| SCHEMBL332843 | 0.81 | ALOX5 (0.52) | ALOX5NPC1MAPTCYP2C9CYP2C19 | |
| SCHEMBL332424 | 0.79 | ALOX5 (0.62) | ALOX5HRH3PIK3CD | |
| SCHEMBL13201380 | 0.78 | ALOX5 (0.58) | ALOX5NPC1MAPTCYP2C9CYP2C19 | |
| SCHEMBL332551 | 0.77 | ALOX5 (0.54) | ALOX5HRH3PIK3CD | |
| SCHEMBL8173632 | 0.75 | ALOX5 (0.67) | ALOX5NPC1MAPTCYP2C9CYP2C19 | |
| SCHEMBL8166180 | 0.74 | ALOX5 (0.67) | ALOX5ALDH1A1HRH3PIK3CDLMNA | |
| Pf-4191834 SCHEMBL332973 | 0.74 | ALOX5 (0.81) | ALOX5HRH3PIK3CD | |
| Pf-4191834 SCHEMBL29369341 | 0.74 | ALOX5 (0.81) | ALOX5HRH3PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8097733-B2 | Pyrazole derivatives as 5-LO-inhibitors | PFIZER INC. (US) | 2012-01-17 | — | — | US | disclosed |
| EP-2225229-A1 | PYRAZOLE DERIVATIVES AS 5-LO INHIBITORS | Pfizer Inc. (US) | 2010-09-08 | — | — | EP | disclosed |
| US-7772269-B2 | Pyrazole analogs | PFIZER INC. (US) | 2010-08-10 | — | — | US | disclosed |
| US-7772269-B2 | Pyrazole analogs | PFIZER INC. (US) | 2010-08-10 | — | — | US | disclosed |
| US-7772269-B2 | Pyrazole analogs | PFIZER INC. (US) | 2010-08-10 | — | — | US | disclosed |
| US-20090227634-A1 | Pyrazole Derivatives as 5-LO-Inhibitors | PFIZER INC. | 2009-09-10 | — | — | US | disclosed |
| EP-2097407-A1 | PYRAZOLE ANALOGS | Pfizer Products Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2009069044-A1 | PYRAZOLE DERIVATIVES AS 5-LO INHIBITORS | PFIZER INC. (US) | 2009-06-04 | — | — | WO | disclosed |
| WO-2008065493-A1 | PYRAZOLE ANALOGS | PFIZER PRODUCTS INC. (US) | 2008-06-05 | — | — | WO | disclosed |
| WO-2008065493-A1 | PYRAZOLE ANALOGS | PFIZER PRODUCTS INC. (US) | 2008-06-05 | — | — | WO | disclosed |
| US-20080125474-A1 | Pyrazole Analogs | PFIZER INC. | 2008-05-29 | — | — | US | disclosed |
| US-20080125474-A1 | Pyrazole Analogs | PFIZER INC. | 2008-05-29 | — | — | US | disclosed |
| US-20080125474-A1 | Pyrazole Analogs | PFIZER INC. | 2008-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227634-A1 | Pyrazole Derivatives as 5-LO-Inhibitors | ALOX5, ALOX15, CYP3A5 | ALOX5 1/4885NPC1 1623/4885MAPT 4364/4885 |
| US-20080125474-A1 | Pyrazole Analogs | IL33, CFTR, HRH1 | ALOX5 949/4885NPC1 472/4885MAPT 2908/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.