Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 15/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 12/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL243584 | 0.90 | PIK3CA (0.41) | PIK3CAPIK3R1MAPK1PIK3CDPIK3CB | |
| SCHEMBL244726 | 0.86 | PIK3CA (0.40) | PIK3CAPIK3R1MAPK1KDM4EHTT | |
| SCHEMBL243285 | 0.83 | PIK3CA (0.40) | PIK3CAPIK3R1KDM4EHTTMTOR | |
| SCHEMBL14803578 | 0.82 | ADORA2A (0.47) | PIK3CAPIK3R1PIK3CDPIK3CBKDM4E | |
| SCHEMBL3108283 | 0.77 | PIK3CA (0.42) | PIK3CAPIK3R1MAPK1PIK3CDPIK3CB | |
| SCHEMBL3342182 | 0.73 | GPR119 (0.41) | PIK3CAMTOR | |
| SCHEMBL243583 | 0.73 | PIK3CA (0.43) | PIK3CAPIK3R1PIK3CDPIK3CBKDM4E | |
| SCHEMBL3344414 | 0.72 | ALDH1A1 (0.39) | PIK3CAPIK3R1MAPK1KDM4EMTOR | |
| SCHEMBL1458406 | 0.72 | PIK3CA (0.54) | PIK3CAPIK3R1PIK3CDPIK3CBKDM4E | |
| SCHEMBL3994283 | 0.71 | LMNA (0.41) | PIK3CAPIK3CDPIK3CBHTTMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003264-A1 | NITROGEN CONTAINING HETEROCYCLIC COMPOUNDS AS PIK3 -DELTA INHIBITORS | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |