Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3325133 | 1.00 | HTR1A (0.48) | HTR1ASLC6A2SLC6A4CHRNB4CHRNA3 | |
| SCHEMBL3325733 | 0.86 | SLC6A2 (0.51) | HTR1ASLC6A2SLC6A4CHRNB4CHRNA3 | |
| SCHEMBL3329940 | 0.86 | SLC6A2 (0.51) | HTR1ASLC6A2SLC6A4CHRNB4CHRNA3 | |
| SCHEMBL3324752 | 0.85 | CHRNB4 (0.46) | HTR1ASLC6A2SLC6A4CHRNB4CHRNA3 | |
| SCHEMBL3324758 | 0.85 | CHRNB4 (0.46) | HTR1ASLC6A2SLC6A4CHRNB4CHRNA3 | |
| SCHEMBL3330214 | 0.84 | IKBKB (0.46) | HTR1ASLC6A2SLC6A4CHRNB4CHRNA3 | |
| SCHEMBL3330413 | 0.84 | IKBKB (0.46) | HTR1ASLC6A2SLC6A4CHRNB4CHRNA3 | |
| SCHEMBL3323314 | 0.84 | IKBKB (0.46) | CHRNB4CHRNA3IKBKBCHUKKDM1A | |
| SCHEMBL3328733 | 0.84 | IKBKB (0.46) | CHRNB4CHRNA3IKBKBCHUKKDM1A | |
| SCHEMBL3323225 | 0.83 | HTR1A (0.54) | HTR1ASLC6A2SLC6A4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100120858-A1 | Piperidine Derivatives | PFIZER INC. | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120858-A1 | Piperidine Derivatives | P2RX5, P2RX7, P2RX1 | HTR1A 302/4885SLC6A2 2609/4885SLC6A4 1898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.