Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 6/20 | 0.38 |
| ▸ | NOS2 | P35228 | 6/20 | 0.38 |
| ▸ | NOS3 | P29474 | 5/20 | 0.38 |
| ▸ | DDAH1 | O94760 | 4/20 | 0.38 |
| ▸ | GSR | P00390 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPY4R | P50391 | 4/20 | 0.34 |
| ▸ | NPY1R | P25929 | 3/20 | 0.34 |
| ▸ | NPY2R | P49146 | 2/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL904454 | 0.88 | OTC (0.41) | OTCNOS1NOS2NOS3DDAH1 | |
| Arginine SCHEMBL6130138 | 0.85 | GSR (0.46) | OTCNOS1NOS2NOS3DDAH1 | |
| SCHEMBL1965668 | 0.85 | NPY4R (0.38) | OTCNOS1NOS2NOS3DDAH1 | |
| Arginine SCHEMBL27983903 | 0.82 | OTC (0.43) | OTCNOS1NOS2NOS3DDAH1 | |
| Arginine SCHEMBL28224090 | 0.82 | OTC (0.43) | OTCNOS1NOS2NOS3DDAH1 | |
| Arginine SCHEMBL10876829 | 0.82 | GSR (0.43) | OTCNOS1NOS2NOS3DDAH1 | |
| Arginine SCHEMBL25212883 | 0.82 | OTC (0.47) | OTCNOS1NOS2NOS3DDAH1 | |
| Arginine SCHEMBL4586460 | 0.82 | OTC (0.47) | OTCNOS1NOS2NOS3DDAH1 | |
| Arginine SCHEMBL4586458 | 0.82 | OTC (0.47) | OTCNOS1NOS2NOS3DDAH1 | |
| Arginine SCHEMBL2762369 | 0.81 | OTC (0.42) | OTCNOS1NOS2NOS3DDAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846866-B2 | Aldehyde tags, uses thereof in site-specific protein modification | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-09-30 | — | — | US | claimed |
| US-20130203111-A1 | Aldehyde Tags, Uses Thereof in Site-Specific Protein Modification | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-08-08 | — | — | US | claimed |
| US-20210024614-A1 | Aldehyde Tags, Uses Thereof in Site-Specific Protein Modification | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2021-01-28 | — | — | US | disclosed |
| US-10745464-B2 | Aldehyde tags, uses thereof in site-specific protein modification | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-08-18 | — | — | US | disclosed |
| US-20190153070-A1 | Aldehyde Tags, Uses Thereof in Site-Specific Protein Modification | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-05-23 | — | — | US | disclosed |
| US-10150806-B2 | Aldehyde tags, uses thereof in site-specific protein modification | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-12-11 | — | — | US | disclosed |
| US-20170121389-A1 | Aldehyde Tags, Uses Thereof in Site-Specific Protein Modification | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2017-05-04 | — | — | US | disclosed |
| EP-2548967-B1 | Aldehyde tags, uses thereof in site-specific protein modification | UNIV CALIFORNIA (US) | 2016-12-28 | — | — | EP | disclosed |
| US-9447390-B2 | Aldehyde tags, uses thereof in site-specific protein modification | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-09-20 | — | — | US | disclosed |
| US-20150072398-A1 | Aldehyde Tags, Uses Thereof in Site-Specific Protein Modification | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-03-12 | — | — | US | disclosed |
| US-8846866-B2 | Aldehyde tags, uses thereof in site-specific protein modification | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-09-30 | — | — | US | disclosed |
| US-8097701-B2 | Aldehyde tags, uses thereof in site-specific protein modification | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-01-17 | — | — | US | disclosed |
| US-20110287041-A1 | Aldehyde Tags, Uses Thereof in Site-Specific Protein Modification | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2011-11-24 | — | — | US | disclosed |
| US-20110250704-A1 | Aldehyde Tags, Uses Thereof in Site-Specific Protein Modification | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2011-10-13 | — | — | US | disclosed |
| US-7985783-B2 | Aldehyde tags, uses thereof in site-specific protein modification | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-07-26 | — | — | US | disclosed |
| US-20110117621-A1 | Aldehyde Tags, Uses Thereof in Site-Specific Protein Modification | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2011-05-19 | — | — | US | disclosed |
| WO-2009120611-A2 | ALDEHYDE TAGS, USES THEREOF IN SITE-SPECIFIC PROTEIN MODIFICATION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-10-01 | — | — | WO | disclosed |
| EP-2064334-A2 | ALDEHYDE TAGS, USES THEREOF IN SITE-SPECIFIC PROTEIN MODIFICATION | The Regents of the University of California (US) | 2009-06-03 | — | — | EP | disclosed |
| US-20080187956-A1 | Modification at sulfatase motif of aldehyde tag through action of a formylglycine generating enzyme (FGE) generates formylglycine (FGly) residue | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-08-07 | — | — | US | disclosed |
| WO-2008036350-A2 | ALDEHYDE TAGS, USES THEREOF IN SITE-SPECIFIC PROTEIN MODIFICATION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130203111-A1 | Aldehyde Tags, Uses Thereof in Site-Specific Protein Modification | PFAS, DNPEP, ANPEP | OTC 1609/4885NOS1 4088/4885NOS2 4186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.