Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.81 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.81 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.81 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.81 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.68 |
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.68 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.65 |
| ▸ | STAT3 | P40763 | 4/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.65 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.65 |
| ▸ | RELA | Q04206 | 3/20 | 0.65 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.65 |
| ▸ | MET | P08581 | 3/20 | 0.56 |
| ▸ | PTGES | O14684 | 2/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | APP | P05067 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3335463 | 1.00 | CYP1A2 (0.81) | CYP1A2CYP2D6CYP3A4CYP2C9CYP2B6 | |
| SCHEMBL2743841 | 0.90 | CYP1A2 (1.00) | CYP1A2CYP2D6CYP3A4CYP2C9CYP2B6 | |
| SCHEMBL2743839 | 0.90 | CYP1A2 (1.00) | CYP1A2CYP2D6CYP3A4CYP2C9CYP2B6 | |
| SCHEMBL28741079 | 0.85 | CYP1A2 (0.58) | CYP1A2CYP2D6CYP3A4CYP2C9CYP2B6 | |
| SCHEMBL30179914 | 0.83 | CYP1A2 (0.87) | CYP1A2CYP2D6CYP3A4CYP2C9CYP2B6 | |
| SCHEMBL626598 | 0.83 | CYP2D6 (0.82) | CYP1A2CYP2D6CYP3A4CYP2C9CYP2B6 | |
| SCHEMBL626599 | 0.83 | CYP2D6 (0.82) | CYP1A2CYP2D6CYP3A4CYP2C9CYP2B6 | |
| SCHEMBL29428460 | 0.82 | KDM4E (0.69) | CYP1A2CYP2D6ALOX5STAT3NFKB1 | |
| SCHEMBL7051812 | 0.81 | JUN (0.59) | CYP1A2CYP2D6CYP3A4CYP2C9CYP2B6 | |
| SCHEMBL15598669 | 0.81 | APP (0.79) | CYP1A2CYP2D6CYP3A4CYP2C9CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100152493-A1 | BIS(ARYLMETHYLIDENE)ACETONE COMPOUND, ANTI-CANCER AGENT, CARCINOGENESIS-PREVENTIVE AGENT, INHIBITOR OF EXPRESSION OF Ki-Ras, ErbB2, c-Myc AND CYCLINE D1, BETA-CATENIN-DEGRADING AGENT, AND p53 EXPRESSION ENHANCER | SHIBATA, HIROYUKI (JP) | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152493-A1 | BIS(ARYLMETHYLIDENE)ACETONE COMPOUND, ANTI-CANCER AGENT, CARCINOGENESIS-PREVENTIVE AGENT, INHIBITOR OF EXPRESSION OF Ki-Ras, ErbB2, c-Myc AND CYCLINE D1, BETA-CATENIN-DEGRADING AGENT, AND p53 EXPRESSION ENHANCER | MYC, CCNE2, CCNE1 | CYP1A2 1717/4885CYP2D6 1871/4885CYP3A4 2309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.