Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 7/20 | 0.68 |
| ▸ | DRD5 | P21918 | 6/20 | 0.68 |
| ▸ | DRD4 | P21917 | 5/20 | 0.68 |
| ▸ | HRH1 | P35367 | 10/20 | 0.58 |
| ▸ | DRD3 | P35462 | 4/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10506424 | 0.99 | DRD1 (0.67) | DRD1DRD5DRD4HRH1DRD3 | |
| SCHEMBL3336256 | 0.81 | LTA4H (0.67) | HRH1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL10506417 | 0.80 | LTA4H (0.65) | HRH1L3MBTL1 | |
| SCHEMBL11750789 | 0.75 | HRH1 (0.90) | DRD1DRD5DRD4HRH1DRD3 | |
| SCHEMBL11629837 | 0.74 | HRH1 (1.00) | DRD1DRD5DRD4HRH1DRD3 | |
| SCHEMBL9271263 | 0.73 | HRH1 (0.69) | DRD1DRD5DRD4HRH1DRD3 | |
| Hydrochloric Acid SCHEMBL11749025 | 0.73 | HRH1 (0.97) | DRD1DRD5DRD4HRH1DRD3 | |
| SCHEMBL14578191 | 0.73 | DRD1 (0.83) | DRD1DRD5DRD4HRH1DRD3 | |
| Hydrochloric Acid SCHEMBL28062266 | 0.72 | POLB (0.51) | L3MBTL1LMNAMAPT | |
| SCHEMBL5004402 | 0.71 | HRH1 (0.70) | DRD1DRD5DRD4HRH1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0153160-B1 | NOVEL CYTOTOXIC AMINOALKYL PHENOL ETHERS | The University of Manitoba (CA) | 1989-05-10 | — | — | EP | claimed |
| EP-0153160-A1 | Novel cytotoxic aminoalkyl phenol ethers | The University of Manitoba (CA) | 1985-08-28 | — | — | EP | claimed |
| US-20100144660-A1 | USE OF N,N-DIETHYL-2-[-4-(PHENYLMETHYL)-PHENOXY]ETHANAMINE MONOHYDROCHLORIDE (DPPE) IN CANCER THEREAPY | YM BIOSCIENCES INC. (CA) | 2010-06-10 | — | — | US | disclosed |
| US-20040248986-A1 | Use of n,n-diethyl-2-{-4-(phenylmethyl) - phenoxy} ethanamine monohydrochloride (dppe) in cancer therapy | MANITOBA, UNIVERSITY OF (CA) | 2004-12-09 | — | — | US | disclosed |
| EP-1441710-A1 | USE OF N,N-DIETHYL-2- -4-(PHENYLMETHYL)-PHENOXY ETHANAMINE MONOHYDROCHLORIDE (DPPE) IN CANCER THERAPY | Vincent Research & Consulting, Inc. (CA) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003037318-A1 | USE OF N,N-DIETHYL-2-[-4-(PHENYLMETHYL)-PHENOXY]ETHANAMINE MONOHYDROCHLORIDE (DPPE) IN CANCER THERAPY | YM BIOSCIENCES, INC. (CA) | 2003-05-08 | — | — | WO | disclosed |
| US-4803227-A | N,N-DIALKYL-2-//4-PHENYLMETHYL/PHENOXY/ETHANAMINE AND TAMOXIFE N | THE UNIVERSITY OF MANITOBA (CA) | 1989-02-07 | — | — | US | disclosed |
| EP-0153160-A1 | Novel cytotoxic aminoalkyl phenol ethers | The University of Manitoba (CA) | 1985-08-28 | — | — | EP | disclosed |