Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 9/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | HTR1A | P08908 | 4/20 | 0.67 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.67 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | DRD1 | P21728 | 5/20 | 0.54 |
| ▸ | DRD2 | P14416 | 4/20 | 0.54 |
| ▸ | DRD4 | P21917 | 4/20 | 0.54 |
| ▸ | DRD5 | P21918 | 4/20 | 0.54 |
| ▸ | DRD3 | P35462 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11033196 | 0.85 | HPGD (0.81) | HRH1HPGDSMN1; SMN2HTR1AADRA1D | |
| SCHEMBL9271263 | 0.84 | HRH1 (0.69) | HRH1HPGDSMN1; SMN2HTR1AADRA1D | |
| SCHEMBL5145157 | 0.84 | HPGD (0.78) | HRH1HPGDSMN1; SMN2HTR1AADRA1D | |
| SCHEMBL11031853 | 0.84 | HPGD (0.96) | HRH1HPGDSMN1; SMN2HTR1AADRA1D | |
| Hydrochloric Acid SCHEMBL5007390 | 0.84 | HRH1 (0.78) | HRH1HPGDSMN1; SMN2HTR1AADRA1D | |
| Hydrochloric Acid SCHEMBL11631075 | 0.83 | HPGD (0.81) | HRH1HPGDSMN1; SMN2HTR1AADRA1D | |
| SCHEMBL11629837 | 0.83 | HRH1 (1.00) | HRH1HPGDSMN1; SMN2HTR1AADRA1D | |
| Hydrochloric Acid SCHEMBL5007389 | 0.82 | HTR1A (0.60) | HRH1HPGDSMN1; SMN2HTR1AADRA1D | |
| SCHEMBL11752036 | 0.82 | HRH1 (0.75) | HRH1HPGDSMN1; SMN2HTR1AADRA1D | |
| Hydrochloric Acid SCHEMBL11749025 | 0.81 | HRH1 (0.97) | HRH1HPGDSMN1; SMN2HTR1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414063-B2 | Inhibitors of Akt (protein kinase B) | ELI LILLY AND COMPANY (US) | 2008-08-19 | — | — | US | disclosed |
| US-20070043040-A1 | Inhibitors of akt (protein kinase b) | ELI LILLY AND COMPANY | 2007-02-22 | — | — | US | disclosed |
| EP-1611105-A1 | ISOQUINOLINE-5-SULFONIC ACID AMIDES AS INHIBITORS OF AKT (PROTEIN KINASE B) | ELI LILLY AND COMPANY (US) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004094386-A1 | ISOQUINOLINE-5-SULFONIC ACID AMIDES AS INHIBITORS OF AKT (PROTEIN KINASE B) | ELI LILLY AND COMPANY (US) | 2004-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043040-A1 | Inhibitors of akt (protein kinase b) | AKT1, AKT2, BRAF | HRH1 3593/4885HPGD 3799/4885SMN1; SMN2 2866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.