Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | HPGD | P15428 | 6/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.63 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.63 |
| ▸ | MPO | P05164 | 3/20 | 0.62 |
| ▸ | XDH | P47989 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27432025 | 0.84 | MPO (0.65) | SMN1; SMN2LMNAHPGDCYP1A2CYP3A4 | |
| SCHEMBL12713472 | 0.81 | KDM4E (0.70) | SMN1; SMN2LMNAHPGDCYP1A2CYP3A4 | |
| SCHEMBL12713432 | 0.80 | MPO (0.73) | SMN1; SMN2ALDH1A1MPOXDHMAPT | |
| SCHEMBL7648079 | 0.80 | ALDH1A1 (0.74) | SMN1; SMN2HPGDALDH1A1GAAMPO | |
| SCHEMBL10288918 | 0.80 | MPO (0.68) | SMN1; SMN2HPGDCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL6293995 | 0.79 | ALDH1A1 (0.68) | SMN1; SMN2HPGDALDH1A1GAAMPO | |
| SCHEMBL10288919 | 0.79 | MPO (0.67) | SMN1; SMN2HPGDCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL10289176 | 0.78 | MPO (0.65) | SMN1; SMN2HPGDCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL2731546 | 0.77 | MPO (1.00) | ALDH1A1MPOXDH | |
| SCHEMBL10289185 | 0.77 | MPO (1.00) | SMN1; SMN2ALDH1A1MPOXDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144714-A1 | DERIVATIVES OF IMIDAZO PYRIMIDO AND DIAZEPINE PYRIMIDINE-DIONE, AND USE THEREOF AS A DRUG | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2010-06-10 | — | — | US | disclosed |
| EP-2129675-A2 | DERIVATIVES OF IMIDAZO, PYRIMIDO AND DIAZEPINE PYRIMIDINE-DIONE, AND USE THEREOF AS A DRUG | IPSEN PHARMA S.A.S. (FR) | 2009-12-09 | — | — | EP | disclosed |
| WO-2008090286-A2 | DERIVATIVES OF IMIDAZO, PYRIMIDO AND DIAZEPINE PYRIMIDINE-DIONE, AND USE THEREOF AS A DRUG | IPSEN PHARMA S.A.S. (FR) | 2008-07-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144714-A1 | DERIVATIVES OF IMIDAZO PYRIMIDO AND DIAZEPINE PYRIMIDINE-DIONE, AND USE THEREOF AS A DRUG | CNR1, CNR2, TBXA2R | SMN1; SMN2 4012/4885LMNA 3153/4885HPGD 1087/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.