Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 13/20 | 0.68 |
| ▸ | RAB9A | P51151 | 13/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.58 |
| ▸ | PKM | P14618 | 6/20 | 0.58 |
| ▸ | HPGD | P15428 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.58 |
| ▸ | TP53 | P04637 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6258373 | 0.86 | NPC1 (0.69) | NPC1RAB9AKDM4ESMN1; SMN2GAA | |
| SCHEMBL6247334 | 0.85 | NPC1 (0.65) | NPC1RAB9AKDM4ESMN1; SMN2GAA | |
| SCHEMBL23743192 | 0.83 | NPC1 (0.59) | NPC1RAB9AKDM4ESMN1; SMN2GAA | |
| SCHEMBL24075329 | 0.83 | KDM4E (0.68) | NPC1RAB9AKDM4ESMN1; SMN2GAA | |
| SCHEMBL28117058 | 0.82 | NPC1 (0.69) | NPC1RAB9AKDM4ESMN1; SMN2GAA | |
| SCHEMBL4175670 | 0.82 | NPC1 (0.61) | NPC1RAB9AKDM4ESMN1; SMN2GAA | |
| SCHEMBL17255145 | 0.82 | NPC1 (0.50) | NPC1RAB9AKDM4ESMN1; SMN2GAA | |
| SCHEMBL29386825 | 0.82 | NPC1 (0.88) | NPC1RAB9AKDM4ESMN1; SMN2GAA | |
| SCHEMBL2178266 | 0.82 | NPC1 (0.88) | NPC1RAB9AKDM4ESMN1; SMN2GAA | |
| SCHEMBL3337878 | 0.81 | NPC1 (1.00) | NPC1RAB9AKDM4ESMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198307-B2 | Imidazole derivatives having aryl piperidine substituent, method for preparation thereof and pharmaceutical compositions containing same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2012-06-12 | — | — | US | disclosed |
| US-20100145054-A1 | IMIDAZOLE DERIVATIVES HAVING ARYL PIPERIDINE SUBSTITUENT, METHOD FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100145054-A1 | IMIDAZOLE DERIVATIVES HAVING ARYL PIPERIDINE SUBSTITUENT, METHOD FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | TYR, MCHR1, MCHR2 | NPC1 223/4885RAB9A 687/4885KDM4E 220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.