Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.59 |
| ▸ | RAB9A | P51151 | 10/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.51 |
| ▸ | PKM | P14618 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14004135 | 0.85 | TRPV1 (0.51) | NPC1RAB9ASMN1; SMN2KDM4EPOLB | |
| SCHEMBL24075192 | 0.84 | KDM4E (0.57) | KDM4EALDH1A1HPGDHSD17B10DGAT1 | |
| SCHEMBL3336689 | 0.83 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2KDM4EGAA | |
| SCHEMBL23743186 | 0.81 | TNKS (0.66) | NPC1RAB9AKDM4EALDH1A1PKM | |
| SCHEMBL21642815 | 0.78 | ALOX5 (0.50) | KDM4EALDH1A1HPGDHSD17B10NPBWR1 | |
| SCHEMBL29784963 | 0.77 | HDAC6 (0.71) | NPC1RAB9ASMN1; SMN2KDM4EGAA | |
| SCHEMBL724591 | 0.77 | HDAC6 (0.71) | NPC1RAB9ASMN1; SMN2KDM4EGAA | |
| SCHEMBL21705326 | 0.77 | NPBWR1 (0.67) | NPC1RAB9ASMN1; SMN2KDM4EGAA | |
| SCHEMBL6258373 | 0.77 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2KDM4EGAA | |
| SCHEMBL30011485 | 0.77 | NPBWR1 (0.67) | NPC1RAB9ASMN1; SMN2KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210246109-A1 | POTENT AND SELECTIVE INHIBITORS OF CYTOCHROME P450 | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2021-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210246109-A1 | POTENT AND SELECTIVE INHIBITORS OF CYTOCHROME P450 | CYP11B1, CYP1B1, CYP27A1 | NPC1 751/4885RAB9A 1418/4885SMN1; SMN2 3044/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.