Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.60 |
| ▸ | RAB9A | P51151 | 6/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | PKM | P14618 | 4/20 | 0.60 |
| ▸ | HPGD | P15428 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | TP53 | P04637 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.57 |
| ▸ | RELA | Q04206 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.53 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23758272 | 0.91 | NPC1 (0.64) | NPC1SMN1; SMN2RAB9AALDH1A1KDM4E | |
| SCHEMBL17393373 | 0.87 | SMN1; SMN2 (0.65) | NPC1SMN1; SMN2RAB9AALDH1A1KDM4E | |
| SCHEMBL6262977 | 0.85 | NPC1 (0.79) | NPC1SMN1; SMN2RAB9AALDH1A1KDM4E | |
| SCHEMBL2324292 | 0.85 | NPC1 (0.78) | NPC1SMN1; SMN2RAB9AALDH1A1KDM4E | |
| SCHEMBL419326 | 0.84 | NPC1 (0.71) | NPC1SMN1; SMN2RAB9AALDH1A1KDM4E | |
| SCHEMBL1170729 | 0.84 | ALDH1A1 (0.57) | NPC1SMN1; SMN2RAB9AALDH1A1KDM4E | |
| SCHEMBL17255208 | 0.84 | RAB9A (0.59) | NPC1SMN1; SMN2RAB9AALDH1A1KDM4E | |
| SCHEMBL30108052 | 0.84 | ALDH1A1 (0.58) | NPC1SMN1; SMN2RAB9AALDH1A1KDM4E | |
| SCHEMBL21705378 | 0.83 | HDAC6 (0.61) | NPC1SMN1; SMN2RAB9AALDH1A1KDM4E | |
| SCHEMBL31027945 | 0.83 | HDAC6 (0.61) | NPC1SMN1; SMN2RAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198307-B2 | Imidazole derivatives having aryl piperidine substituent, method for preparation thereof and pharmaceutical compositions containing same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2012-06-12 | — | — | US | disclosed |
| US-20100145054-A1 | IMIDAZOLE DERIVATIVES HAVING ARYL PIPERIDINE SUBSTITUENT, METHOD FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100145054-A1 | IMIDAZOLE DERIVATIVES HAVING ARYL PIPERIDINE SUBSTITUENT, METHOD FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | TYR, MCHR1, MCHR2 | NPC1 223/4885SMN1; SMN2 1895/4885RAB9A 687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.