Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | PKM | P14618 | 2/20 | 0.64 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.54 |
| ▸ | RELA | Q04206 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3337335 | 0.91 | NPC1 (0.60) | NPC1SMN1; SMN2ALDH1A1RAB9AKDM4E | |
| SCHEMBL20445326 | 0.88 | SLC2A1 (0.68) | NPC1SMN1; SMN2ALDH1A1RAB9AKDM4E | |
| SCHEMBL419326 | 0.88 | NPC1 (0.71) | NPC1SMN1; SMN2ALDH1A1RAB9AKDM4E | |
| SCHEMBL9032997 | 0.87 | ALDH1A1 (0.62) | NPC1SMN1; SMN2ALDH1A1RAB9AKDM4E | |
| SCHEMBL17393735 | 0.87 | RAB9A (0.65) | NPC1SMN1; SMN2ALDH1A1RAB9AKDM4E | |
| SCHEMBL3335014 | 0.86 | ALDH1A1 (0.61) | NPC1SMN1; SMN2ALDH1A1RAB9AKDM4E | |
| SCHEMBL23758270 | 0.85 | AURKA (0.55) | NPC1SMN1; SMN2ALDH1A1RAB9AKDM4E | |
| SCHEMBL465444 | 0.84 | ACHE (0.64) | ALDH1A1KDM4ETP53HPGDMEN1 | |
| SCHEMBL17255157 | 0.84 | RAB9A (0.56) | NPC1SMN1; SMN2ALDH1A1RAB9AKDM4E | |
| SCHEMBL12470638 | 0.84 | NPC1 (0.66) | NPC1SMN1; SMN2ALDH1A1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11090289-B2 | Compositions and methods for blocking sodium channels | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2021-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11090289-B2 | Compositions and methods for blocking sodium channels | SCN3A, SCN1B, SCN2B | NPC1 483/4885SMN1; SMN2 228/4885ALDH1A1 2497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.