Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PGD | P52209 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.33 |
| ▸ | GMNN | O75496 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.33 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26329338 | 0.81 | — | — | |
| SCHEMBL27647482 | 0.81 | GABRR1 (0.41) | LMNASMN1; SMN2PGDCYP1A2SLC22A6 | |
| SCHEMBL29130353 | 0.81 | SMN1; SMN2 (0.35) | LMNASMN1; SMN2PGDCYP1A2SLC22A6 | |
| SCHEMBL29130349 | 0.81 | SMN1; SMN2 (0.35) | LMNASMN1; SMN2PGDCYP1A2SLC22A6 | |
| SCHEMBL18327243 | 0.79 | CACNA2D1 (0.47) | LMNASMN1; SMN2PGDSLC22A6CTSS | |
| SCHEMBL25098960 | 0.78 | LMNA (0.58) | LMNASMN1; SMN2CYP1A2MAPK1GMNN | |
| SCHEMBL25098996 | 0.78 | LMNA (0.58) | LMNASMN1; SMN2CYP1A2MAPK1GMNN | |
| SCHEMBL28841656 | 0.78 | POLB (0.30) | — | |
| SCHEMBL3043003 | 0.77 | LMNA (0.41) | LMNASMN1; SMN2CYP1A2MAPK1GMNN | |
| SCHEMBL24239083 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9643911-B2 | Treprostinil derivatives and compositions and uses thereof | Corsair Pharma, Inc. (US) | 2017-05-09 | — | — | US | disclosed |
| US-20160368855-A1 | TREPROSTINIL DERIVATIVES AND COMPOSITIONS AND USES THEREOF | Corsair Pharma, Inc. | 2016-12-22 | — | — | US | disclosed |
| JP-2010138096-A | METHOD FOR PRODUCING 2-t-BUTOXYETHYL ACETATE OR 1-(t-BUTOXY)-2-PROPYL ACETATE | CHISSO CORP | 2010-06-24 | — | — | JP | disclosed |
| JP-2010138096-A | METHOD FOR PRODUCING 2-t-BUTOXYETHYL ACETATE OR 1-(t-BUTOXY)-2-PROPYL ACETATE | CHISSO CORP | 2010-06-24 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160368855-A1 | TREPROSTINIL DERIVATIVES AND COMPOSITIONS AND USES THEREOF | PTGIS, PTGIR, PDE3A | LMNA 1825/4885SMN1; SMN2 3016/4885PGD 381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.