Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23270129 | 0.88 | HDAC4 (0.31) | — | |
| SCHEMBL1627286 | 0.85 | ALDH1A1 (0.38) | MAP3K12 | |
| SCHEMBL28689628 | 0.80 | CNR1 (0.39) | MAP3K12 | |
| SCHEMBL4006359 | 0.79 | ALDH1A1 (0.37) | MAP3K12 | |
| SCHEMBL17025860 | 0.79 | HDAC6 (0.40) | MAP3K12 | |
| SCHEMBL625872 | 0.77 | SLC6A4 (0.38) | MAP3K12 | |
| SCHEMBL333096 | 0.76 | PDE1A (0.32) | MAP3K12 | |
| SCHEMBL28677184 | 0.74 | ALDH1A1 (0.41) | MAP3K12 | |
| SCHEMBL28678474 | 0.72 | SLC6A4 (0.40) | — | |
| SCHEMBL3868254 | 0.72 | HDAC4 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8097733-B2 | Pyrazole derivatives as 5-LO-inhibitors | PFIZER INC. (US) | 2012-01-17 | — | — | US | disclosed |
| US-20090227634-A1 | Pyrazole Derivatives as 5-LO-Inhibitors | PFIZER INC. | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227634-A1 | Pyrazole Derivatives as 5-LO-Inhibitors | ALOX5, ALOX15, CYP3A5 | MAP3K12 2120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.