Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 3/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.40 |
| ▸ | APOB | P04114 | 4/20 | 0.40 |
| ▸ | MTTP | P55157 | 4/20 | 0.40 |
| ▸ | SMO | Q99835 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4770555 | 0.78 | NPC1 (0.51) | RORCTP53LMNAUSP2MAPK1 | |
| Trifluoroacetic Acid SCHEMBL3339970 | 0.75 | PARP1 (0.36) | — | |
| Trifluoroacetic Acid SCHEMBL4765765 | 0.75 | TP53 (0.50) | TP53LMNAHRH3SMN1; SMN2NPC1 | |
| Trifluoroacetic Acid SCHEMBL4770456 | 0.74 | NPC1 (0.52) | TP53HRH3SMN1; SMN2NPC1MAPT | |
| Trifluoroacetic Acid SCHEMBL3342708 | 0.74 | PARP1 (0.36) | HRH3 | |
| Trifluoroacetic Acid SCHEMBL4765546 | 0.74 | MEN1 (0.53) | APOBMTTPSMOTP53SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL4774158 | 0.73 | TMPRSS2 (0.55) | TMPRSS2TP53SMN1; SMN2NPC1MAPT | |
| SCHEMBL8208142 | 0.73 | APOB (0.60) | APOBMTTPSMOLMNASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL4770314 | 0.72 | HRH3 (0.52) | TP53MAPK1HRH3SMN1; SMN2NPC1 | |
| SCHEMBL3343262 | 0.72 | MAP4K1 (0.44) | HRH3NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113512-A1 | METHOD OF TREATMENT USING NOVEL ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS | IGNAR DIANE MICHELE | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113512-A1 | METHOD OF TREATMENT USING NOVEL ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS | OPRL1, OPRD1, OPRK1 | CRACR2A 2169/4885RORC 1844/4885TMPRSS2 1354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.