Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 5/20 | 0.38 |
| ▸ | HTR5A | P47898 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12651468 | 0.93 | OPRM1 (0.52) | OPRM1OPRD1OPRK1HDAC1HTR2C | |
| Trifluoroacetic Acid SCHEMBL3342868 | 0.90 | OPRM1 (0.47) | OPRM1OPRD1OPRK1SLC2A1HTR5A | |
| Trifluoroacetic Acid SCHEMBL3342349 | 0.90 | OPRM1 (0.47) | OPRM1OPRD1OPRK1SLC2A1HTR5A | |
| Trifluoroacetic Acid SCHEMBL3339936 | 0.89 | OPRM1 (0.47) | OPRM1OPRD1OPRK1SLC2A1HTR5A | |
| Trifluoroacetic Acid SCHEMBL3341349 | 0.88 | OPRM1 (0.52) | OPRM1OPRD1OPRK1SLC2A1HTR5A | |
| Trifluoroacetic Acid SCHEMBL3338278 | 0.87 | OPRM1 (0.50) | OPRM1OPRD1OPRK1SLC2A1HTR5A | |
| Trifluoroacetic Acid SCHEMBL3340503 | 0.85 | OPRM1 (0.47) | OPRM1OPRD1OPRK1SLC2A1HTR5A | |
| SCHEMBL13335560 | 0.84 | OPRM1 (0.49) | OPRM1OPRD1OPRK1CCR2HDAC1 | |
| SCHEMBL1786245 | 0.83 | OPRM1 (0.52) | OPRM1OPRD1OPRK1HDAC1MEN1 | |
| SCHEMBL12608170 | 0.83 | OPRM1 (0.49) | OPRM1OPRD1OPRK1HDAC1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140323487-A1 | Novel Compounds As Antagonists Or Inverse Agonists At Opioid Receptors | GLAXOSMITHKLINE LLC | 2014-10-30 | — | — | US | disclosed |
| US-20100113512-A1 | METHOD OF TREATMENT USING NOVEL ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS | IGNAR DIANE MICHELE | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113512-A1 | METHOD OF TREATMENT USING NOVEL ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS | OPRL1, OPRD1, OPRK1 | OPRM1 4/4885OPRD1 2/4885OPRK1 3/4885 |
| US-20140323487-A1 | Novel Compounds As Antagonists Or Inverse Agonists At Opioid Receptors | OPRL1, OPRM1, OPRK1 | OPRM1 2/4885OPRD1 4/4885OPRK1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.