Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | SCN1A | P35498 | 1/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.47 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPY2R | P49146 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11756971 | 0.87 | LMNA (0.61) | POLBEPHX2TDP1LMNACYP1A2 | |
| SCHEMBL24244916 | 0.86 | SCN1A (0.56) | POLBEPHX2KMT2AADRB2MEN1 | |
| SCHEMBL22694560 | 0.85 | KMT2A (0.51) | EPHX2KMT2AADRB2MEN1SRD5A1 | |
| SCHEMBL1375168 | 0.84 | GPR119 (0.61) | POLBEPHX2MAPT | |
| SCHEMBL6135447 | 0.84 | ALDH1A1 (0.55) | POLBEPHX2KMT2ASRD5A1SCN1A | |
| SCHEMBL11758763 | 0.83 | PARP10 (0.59) | EPHX2KMT2AADRB2MEN1LMNA | |
| SCHEMBL17869387 | 0.83 | SCN1A (0.51) | POLBEPHX2LMNACYP1A2CYP3A4 | |
| SCHEMBL3910337 | 0.82 | SCN1A (0.58) | POLBEPHX2LMNACYP1A2CYP3A4 | |
| SCHEMBL4682743 | 0.82 | SRD5A1 (0.67) | EPHX2KMT2ATDP1SRD5A1LMNA | |
| SCHEMBL2636897 | 0.82 | EPHX2 (0.60) | EPHX2KMT2AMEN1SRD5A1SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |